Ablasser, Andrea

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D. R., Latz, E., & Fitzgerald, K. A. (2009) · Nature

Inflammasome and immune disordersinterferon and immune responses

Cited by 2,627

The cGAS–STING pathway as a therapeutic target in inflammatory diseases

Decout, A., Katz, J. D., Venkatraman, S., & Ablasser, A. (2021) · Nature Reviews Immunology

interferon and immune responsesImmune Response and Inflammation

Cited by 2,309

CGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING.

Ablasser, A., Goldeck, M., Cavlar, T., Deimling, T., Witte, G., Röhl, I., Hopfner, K.-P., Ludwig, J., & Hornung, V. (2013) · Nature

interferon and immune responsesDNA and Nucleic Acid Chemistry

Cited by 1,695

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

Glück, S., Guey, B., Gulen, M. F., Wolter, K., Kang, T.-W., Schmacke, N. A., Bridgeman, A., Rehwinkel, J., Zender, L., & Ablasser, A. (2017) · Nature Cell Biology

Telomeres, Telomerase, and Senescenceinterferon and immune responses

Cited by 1,196

Targeting STING with covalent small-molecule inhibitors

Haag, S. M., Gulen, M. F., Reymond, L., Gibelin, A., Abrami, L., Decout, A., Heymann, M., van der Goot, F. G., Turcatti, G., Behrendt, R., et al. (2018) · Nature

interferon and immune responsesImmune Response and Inflammation

Cited by 1,178

cGAS–STING drives ageing-related inflammation and neurodegeneration

Gulen, M. F., Samson, N., Keller, A., Schwabenland, M., Liu, C., Glück, S., Thacker, V. V., Favre, L., Mangeat, B., Kroese, L. J., et al. (2023) · Nature

Neuroinflammation and Neurodegeneration Mechanismsinterferon and immune responses

Cited by 1,104

cGAS in action: Expanding roles in immunity and inflammation

Ablasser, A., & Chen, Z. J. (2019) · Science

interferon and immune responsesImmune Response and Inflammation

Cited by 1,077

The cGAS–STING pathway drives type I IFN immunopathology in COVID-19

Domizio, J. D., Gulen, M. F., Saidoune, F., Thacker, V. V., Yatim, A., Sharma, K., Nass, T., Guenova, E., Schaller, M., Conrad, C., et al. (2022) · Nature

interferon and immune responsesSARS-CoV-2 and COVID-19 Research

Cited by 538

Signalling strength determines proapoptotic functions of STING

Gulen, M. F., Koch, U., Haag, S. M., Schuler, F., Apetoh, L., Villunger, A., Radtke, F., & Ablasser, A. (2017) · Nature Communications

interferon and immune responsesImmune Response and Inflammation

Cited by 505

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1

Wassermann, R., Gulen, M. F., Sala, C., Perin, S. G., Lou, Y., Rybniker, J., Schmid-Burgk, J. L., Schmidt, T., Hornung, V., Cole, S. T., et al. (2015) · Cell Host & Microbe

Tuberculosis Research and Epidemiologyinterferon and immune responses

Cited by 401

Structural mechanism of cGAS inhibition by the nucleosome

Pathare, G. R., Decout, A., Glück, S., Cavadini, S., Makasheva, K., Hovius, R., Kempf, G., Weiss, J., Kozicka, Z., Guey, B., et al. (2020) · Nature

interferon and immune responsesDNA and Nucleic Acid Chemistry

Cited by 273