Seo, Hyuk-Soo

Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands

Gechijian, L. N., Buckley, D. L., Lawlor, M. A., Reyes, J. M., Paulk, J., Ott, C. J., Winter, G. E., Erb, M. A., Scott, T. G., Xu, M., et al. (2018) · Nature Chemical Biology

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 222

Structure-guided development of a potent and selective non-covalent active-site inhibitor of USP7.

Lamberto, I., Liu, X., Seo, H.-S., Schauer, N. J., Iacob, R. E., Hu, W., Das, D., Mikhailova, T., Weisberg, E. L., Engen, J. R., et al. (2017) · Cell Chemical Biology

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 192

Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells

Kozono, S., Lin, Y.-M., Seo, H.-S., Pinch, B., Lian, X., Qiu, C., Herbert, M. K., Chen, C.-H., Tan, L., Gao, Z. J., et al. (2018) · Nature Communications

Signaling Pathways in DiseaseRetinoids in leukemia and cellular processes

Cited by 168

Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling

Fan, M., Lu, W., Che, J., Kwiatkowski, N. P., Gao, Y., Seo, H.-S., Ficarro, S. B., Gokhale, P. C., Liu, Y., Geffken, E. A., et al. (2022) · eLife

Hippo pathway signaling and YAP/TAZCancer-related molecular mechanisms research

Cited by 68

Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma

Nardone, C., Gao, J., Seo, H.-S., Mintseris, J., Ort, L., Yip, M. C. J., Negasi, M., Besschetnova, A. K., Kamitaki, N., Gygi, S. P., et al. (2025) · Molecular Cell

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 22

Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma

Nardone, C., Gao, J., Seo, H.-S., Mintseris, J., Ort, L., Yip, M. C. J., Negasi, M., Besschetnova, A. K., Kamitaki, N., Gygi, S. P., et al. (2025) · Molecular Cell

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 22

Targeting transcription factors through an IMiD independent zinc finger domain

Liu, B. H., Liu, M., Radhakrishnan, S., Dai, M.-Y., Jaladanki, C. K., Gao, C., Tang, J. P., Kumari, K., Go, M. L., Vu, K. A. L., et al. (2025) · EMBO Molecular Medicine

Protein Degradation and InhibitorsChromatin Remodeling and Cancer

Cited by 8