Hildeman, David A.

Mitochondria are required for antigen-specific t cell activation through reactive oxygen species signaling

Sena, L. A., Li, S., Jairaman, A., Prakriya, M., Ezponda, T., Hildeman, D. A., Wang, C.-R., Schumacker, P. T., Licht, J. D., Perlman, H., et al. (2013) · Immunity

T-cell and B-cell ImmunologyMitochondrial Function and Pathology

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An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder

Jordan, M. B., Hildeman, D., Kappler, J., & Marrack, P. (2004) · Blood

Autoimmune and Inflammatory Disorders ResearchImmunodeficiency and Autoimmune Disorders

Cited by 712

Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation

Lages, C. S., Suffia, I., Velilla, P. A., Huang, B., Warshaw, G., Hildeman, D. A., Belkaid, Y., & Chougnet, C. (2008) · The Journal of Immunology

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 399

Etoposide Selectively Ablates Activated T Cells To Control the Immunoregulatory Disorder Hemophagocytic Lymphohistiocytosis

Johnson, T. S., Terrell, C. E., Millen, S. H., Katz, J. D., Hildeman, D. A., & Jordan, M. B. (2014) · The Journal of Immunology

Autoimmune and Inflammatory Disorders ResearchImmunodeficiency and Autoimmune Disorders

Cited by 203

De novo DNA methylation by DNA methyltransferase 3a controls early effector CD8 + T-cell fate decisions following activation

Ladle, B. H., Li, K.-P., Phillips, M. J., Pucsek, A. B., Haile, A., Powell, J. D., Jaffee, E. M., Hildeman, D. A., & Gamper, C. J. (2016) · Proceedings of the National Academy of Sciences

T-cell and B-cell ImmunologyEpigenetics and DNA Methylation

Cited by 152

RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development

Gu, Y., Chae, H.-D., Siefring, J. E., Jasti, A. C., Hildeman, D. A., & Williams, D. A. (2006) · Nature Immunology

T-cell and B-cell ImmunologyProtein Kinase Regulation and GTPase Signaling

Cited by 110

Naturally-aged microglia exhibit phagocytic dysfunction accompanied by gene expression changes reflective of underlying neurologic disease

Thomas, A. L., Lehn, M. A., Janssen, E. M., Hildeman, D. A., & Chougnet, C. A. (2022) · Scientific Reports

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 94

RhoH Regulates Subcellular Localization of ZAP-70 and Lck in T Cell Receptor Signaling

Chae, H.-D., Siefring, J. E., Hildeman, D. A., Gu, Y., & Williams, D. A. (2010) · PLoS ONE

T-cell and B-cell ImmunologyProtein Kinase Regulation and GTPase Signaling

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Implications of inflammatory states on dysfunctional immune responses in aging and obesity

Thomas, A. L., Alarcon, P. C., Divanovic, S., Chougnet, C. A., Hildeman, D. A., & Moreno-Fernandez, M. E. (2021) · Frontiers in Aging

Adipokines, Inflammation, and Metabolic DiseasesImmune responses and vaccinations

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