de Ligt, Joep

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer

Drost, J., van Boxtel, R., Blokzijl, F., Mizutani, T., Sasaki, N., Sasselli, V., de Ligt, J., Behjati, S., Grolleman, J. E., van Wezel, T., et al. (2017) · Science

Cancer Genomics and DiagnosticsDNA Repair Mechanisms

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Building pangenome graphs

Garrison, E., Guarracino, A., Heumos, S., Villani, F., Bao, Z., Tattini, L., Hagmann, J., Vorbrugg, S., Marco-Sola, S., Kubica, C., et al. (2024) · Nature Methods

Genomics and Phylogenetic StudiesGenome Rearrangement Algorithms

Cited by 277

Novel mutations in LRP6 highlight the role of WNT signaling in tooth agenesis

Ockeloen, C. W., Khandelwal, K. D., Dreesen, K., Ludwig, K. U., Sullivan, R., van Rooij, I. A. L. M., Thonissen, M., Swinnen, S., Phan, M., Conte, F., et al. (2016) · Genetics in Medicine

dental development and anomaliesCleft Lip and Palate Research

Cited by 78

Identification of novel human Wnt target genes using adult endodermal tissue-derived organoids

Boonekamp, K. E., Heo, I., Artegiani, B., Asra, P., van Son, G., de Ligt, J., & Clevers, H. (2021) · Developmental Biology

Wnt/β-catenin signaling in development and cancerHippo pathway signaling and YAP/TAZ

Cited by 38

A system-wide approach to monitor responses to synergistic BRAF and EGFR inhibition in colorectal cancer cells

Ressa, A., Bosdriesz, E., de Ligt, J., Mainardi, S., Maddalo, G., Prahallad, A., Jager, M., de la Fonteijne, L., Fitzpatrick, M., Groten, S., et al. (2018) · Molecular & Cellular Proteomics

Colorectal Cancer Treatments and StudiesMelanoma and MAPK Pathways

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