Kloosterhuis, Niels

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

Bartuzi, P., Billadeau, D. D., Favier, R., Rong, S., Dekker, D., Fedoseienko, A., Fieten, H., Wijers, M., Levels, J. H., Huijkman, N., et al. (2016) · Nature Communications

Cholesterol and Lipid MetabolismCellular transport and secretion

Cited by 205

The COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking

Fedoseienko, A., Wijers, M., Wolters, J. C., Dekker, D., Smit, M., Huijkman, N., Kloosterhuis, N., Klug, H., Schepers, A., Willems van Dijk, K., et al. (2018) · Circulation Research

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 126

The hepatocyte IKK:NF-κB axis promotes liver steatosis by stimulating de novo lipogenesis and cholesterol synthesis

Heida, A., Gruben, N., Catrysse, L., Koehorst, M., Koster, M., Kloosterhuis, N. J., Gerding, A., Havinga, R., Bloks, V. W., Bongiovanni, L., et al. (2021) · Molecular Metabolism

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 78

T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice

Bazioti, V., La Rose, A. M., Maassen, S., Bianchi, F., de Boer, R., Halmos, B., Dabral, D., Guilbaud, E., Flohr-Svendsen, A., Groenen, A. G., et al. (2022) · Nature Communications

Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid Metabolism

Cited by 65

The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance

Wijers, M., Zanoni, P., Liv, N., Vos, D. Y., Jäckstein, M. Y., Smit, M., Wilbrink, S., Wolters, J. C., van der Veen, Y. T., Huijkman, N., et al. (2019) · JCI Insight

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 44

A common variant in CCDC93 protects against myocardial infarction and cardiovascular mortality by regulating endosomal trafficking of low-density lipoprotein receptor

Rimbert, A., Dalila, N., Wolters, J. C., Huijkman, N., Smit, M., Kloosterhuis, N., Riemsma, M., van der Veen, Y., Singla, A., van Dijk, F., et al. (2020) · European Heart Journal

Lipoproteins and Cardiovascular HealthGenetic Associations and Epidemiology

Cited by 24

Cargo-Specific Role for Retriever Subunit VPS26C in Hepatocyte Lipoprotein Receptor Recycling to Control Postprandial Triglyceride-Rich Lipoproteins

Vos, D. Y., Wijers, M., Smit, M., Huijkman, N., Kloosterhuis, N. J., Wolters, J. C., Tissink, J. J., Pronk, A. C. M., Kooijman, S., Rensen, P. C. N., et al. (2023) · Arteriosclerosis, Thrombosis, and Vascular Biology

Cholesterol and Lipid MetabolismCellular transport and secretion

Cited by 16