Trapani, Ivana

Effective delivery of large genes to the retina by dual AAV vectors

Trapani, I., Colella, P., Sommella, A., Iodice, C., Cesi, G., de Simone, S., Marrocco, E., Rossi, S., Giunti, M., Palfi, A., et al. (2014) · EMBO Molecular Medicine

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 269

Intein-mediated protein trans-splicing expands adeno-associated virus transfer capacity in the retina

Tornabene, P., Trapani, I., Minopoli, R., Centrulo, M., Lupo, M., de Simone, S., Tiberi, P., Dell’Aquila, F., Marrocco, E., Iodice, C., et al. (2019) · Science Translational Medicine

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 192

Seeing the light after 25 Years of retinal gene therapy

Trapani, I., & Auricchio, A. (2018) · Trends in Molecular Medicine

Retinal Development and DisordersVirus-based gene therapy research

Cited by 124

Efficient gene delivery to the cone-enriched pig retina by dual AAV vectors

Colella, P., Trapani, I., Cesi, G., Sommella, A., Manfredi, A., Puppo, A., Iodice, C., Rossi, S., Simonelli, F., Giunti, M., et al. (2014) · Gene Therapy

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 103

Improved dual AAV vectors with reduced expression of truncated proteins are safe and effective in the retina of a mouse model of Stargardt disease

Trapani, I., Toriello, E., de Simone, S., Colella, P., Iodice, C., Polishchuk, E. V., Sommella, A., Colecchi, L., Rossi, S., Simonelli, F., et al. (2015) · Human Molecular Genetics

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 94

Can Adeno-Associated Viral Vectors Deliver Effectively Large Genes?

Tornabene, P., & Trapani, I. (2020) · Human Gene Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 76

Adeno-Associated Viral Vectors as a Tool for Large Gene Delivery to the Retina

Trapani, I. (2019) · Genes

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 73

Light‐responsive microRNA miR‐211 targets Ezrin to modulate lysosomal biogenesis and retinal cell clearance

Naso, F., Intartaglia, D., Falanga, D., Soldati, C., Polishchuk, E., Giamundo, G., Tiberi, P., Marrocco, E., Scudieri, P., Di Malta, C., et al. (2020) · The EMBO Journal

Retinal Development and DisordersAutophagy in Disease and Therapy

Cited by 46

Inclusion of a degron reduces levels of undesired inteins after AAV-mediated protein trans-splicing in the retina

Tornabene, P., Trapani, I., Centrulo, M., Marrocco, E., Minopoli, R., Lupo, M., Iodice, C., Gesualdo, C., Simonelli, F., Surace, E. M., et al. (2021) · Molecular Therapy - Methods & Clinical Development

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 25

Retinal gene therapy for Stargardt disease with dual AAV intein vectors is both safe and effective in large animal models

Ferla, R., Pugni, E., Lupo, M., Tiberi, P., Fioretto, F., Perota, A., Duchi, R., Lagutina, I., Gesualdo, C., Rossi, S., et al. (2025) · Science Advances

Retinal Development and DisordersVirus-based gene therapy research

Cited by 19

The Opportunities and Challenges of Gene Therapy for Treatment of Inherited Forms of Vision and Hearing Loss

Simons, E. J., & Trapani, I. (2023) · Human Gene Therapy

Retinal Development and DisordersVirus-based gene therapy research

Cited by 14