Degen, Jay L.

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

Davalos, D., Kyu Ryu, J., Merlini, M., Baeten, K. M., Le Moan, N., Petersen, M. A., Deerinck, T. J., Smirnoff, D. S., Bedard, C., Hakozaki, H., et al. (2012) · Nature Communications

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

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Leukocyte engagement of fibrin(ogen) via the integrin receptor αMβ2/Mac-1 is critical for host inflammatory response in vivo

Flick, M. J., Du, X., Witte, D. P., Jiroušková, M., Soloviev, D. A., Busuttil, S. J., Plow, E. F., & Degen, J. L. (2004) · Journal of Clinical Investigation

Cell Adhesion Molecules ResearchBlood properties and coagulation

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The fibrin-derived γ377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease

Adams, R. A., Bauer, J., Flick, M. J., Sikorski, S. L., Nuriel, T., Lassmann, H., Degen, J. L., & Akassoglou, K. (2007) · The Journal of Experimental Medicine

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 335

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

Ryu, J. K., Petersen, M. A., Murray, S. G., Baeten, K. M., Meyer-Franke, A., Chan, J. P., Vagena, E., Bedard, C., Machado, M. R., Coronado, P. E. R., et al. (2015) · Nature Communications

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 271

Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver

Bezerra, J. A., Bugge, T. H., Melin-Aldana, H., Sabla, G., Kombrinck, K. W., Witte, D. P., & Degen, J. L. (1999) · Proceedings of the National Academy of Sciences

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

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