Adelman, Karen

Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq

Replogle, J. M., Saunders, R. A., Pogson, A. N., Hussmann, J. A., Lenail, A., Guna, A., Mascibroda, L., Wagner, E. J., Adelman, K., Lithwick-Yanai, G., et al. (2022) · Cell

CRISPR and Genetic EngineeringSingle-cell and spatial transcriptomics

Cited by 795

Global Analysis of Short RNAs Reveals Widespread Promoter-Proximal Stalling and Arrest of Pol II in Drosophila

Nechaev, S., Fargo, D. C., dos Santos, G., Liu, L., Gao, Y., & Adelman, K. (2010) · Science

Genomics and Chromatin DynamicsRNA Research and Splicing

Cited by 424

Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation

Dorighi, K. M., Swigut, T., Henriques, T., Bhanu, N. V., Scruggs, B. S., Nady, N., Still, C. D., Garcia, B. A., Adelman, K., & Wysocka, J. (2017) · Molecular Cell

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 403

Widespread transcriptional pausing and elongation control at enhancers

Henriques, T., Scruggs, B. S., Inouye, M. O., Muse, G. W., Williams, L. H., Burkholder, A. B., Lavender, C. A., Fargo, D. C., & Adelman, K. (2018) · Genes & Development

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 350

Stable Pausing by RNA Polymerase II Provides an Opportunity to Target and Integrate Regulatory Signals

Henriques, T., Gilchrist, D. A., Nechaev, S., Bern, M., Muse, G. W., Burkholder, A., Fargo, D. C., & Adelman, K. (2013) · Molecular Cell

Genomics and Chromatin DynamicsRNA Research and Splicing

Cited by 240

Integrator recruits protein phosphatase 2A to prevent pause release and facilitate transcription termination

Huang, K.-L., Jee, D., Stein, C. B., Elrod, N. D., Henriques, T., Mascibroda, L. G., Baillat, D., Russell, W. K., Adelman, K., & Wagner, E. J. (2020) · Molecular Cell

Genomics and Chromatin DynamicsRNA Research and Splicing

Cited by 184

Co-transcriptional splicing regulates 3′ end cleavage during mammalian erythropoiesis

Reimer, K. A., Mimoso, C. A., Adelman, K., & Neugebauer, K. M. (2021) · Molecular Cell

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 180

Spt6 enhances the elongation rate of RNA polymerase II in vivo

Ardehali, M. B., Yao, J., Adelman, K., Fuda, N. J., Petesch, S. J., Webb, W. W., & Lis, J. T. (2009) · The EMBO Journal

Genomics and Chromatin DynamicsNuclear Structure and Function

Cited by 157

Intragenic Enhancers Attenuate Host Gene Expression

Cinghu, S., Yang, P., Kosak, J. P., Conway, A. E., Kumar, D., Oldfield, A. J., Adelman, K., & Jothi, R. (2017) · Molecular Cell

Genomics and Chromatin DynamicsCancer-related molecular mechanisms research

Cited by 100

Glucocorticoid receptor represses proinflammatory genes at distinct steps of the transcription cycle

Gupte, R., Muse, G. W., Chinenov, Y., Adelman, K., & Rogatsky, I. (2013) · Proceedings of the National Academy of Sciences

Estrogen and related hormone effectsGenomics and Chromatin Dynamics

Cited by 70