Poso, Antti

Assessment of mutation probabilities of KRAS G12 missense mutants and their long-timescale dynamics by atomistic molecular simulations and Markov state modeling

Pantsar, T., Rissanen, S., Dauch, D., Laitinen, T., Vattulainen, I., & Poso, A. (2018) · PLOS Computational Biology

Protein Kinase Regulation and GTPase SignalingProtein Structure and Dynamics

Cited by 85

The effect of ligand-based tautomer and protomer prediction on structure-based virtual screening.

Kalliokoski, T., Salo, H. S., Lahtela-Kakkonen, M., & Poso, A. (2009) · Journal of Chemical Information and Modeling

Computational Drug Discovery MethodsSynthesis and Characterization of Heterocyclic Compounds

Cited by 66

First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Zwirner, S., Abu Rmilah, A. A., Klotz, S., Pfaffenroth, B., Kloevekorn, P., Moschopoulou, A. A., Schuette, S., Haag, M., Selig, R., Li, K., et al. (2024) · Cell

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 65

Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells

Deen, A. J., Adinolfi, S., Härkönen, J., Patinen, T., Liu, X., Laitinen, T., Takabe, P., Kainulainen, K., Pasonen-Seppänen, S., Gawriyski, L. M., et al. (2024) · Redox Biology

Genomics, phytochemicals, and oxidative stressNF-κB Signaling Pathways

Cited by 27

Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells

Deen, A. J., Adinolfi, S., Härkönen, J., Patinen, T., Liu, X., Laitinen, T., Takabe, P., Kainulainen, K., Pasonen-Seppänen, S., Gawriyski, L. M., et al. (2023) · Redox Biology

Genomics, phytochemicals, and oxidative stressNF-κB Signaling Pathways

Cited by 27

PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2

Karim, M., Mishra, M., Lo, C.-W., Saul, S., Cagirici, H. B., Gourdelier, M., Ghita, L., Ojha, A., Tran, D. H. N., Agrawal, A., et al. (2025) · Nature Communications

SARS-CoV-2 and COVID-19 ResearchAutophagy in Disease and Therapy

Cited by 16

The comprehensive SARS-CoV-2 ‘hijackome’ knowledge base

Huuskonen, S., Liu, X., Pöhner, I., Redchuk, T., Salokas, K., Lundberg, R., Maljanen, S., Belik, M., Reinholm, A., Kolehmainen, P., et al. (2024) · Cell Discovery

SARS-CoV-2 and COVID-19 ResearchAdvanced Proteomics Techniques and Applications

Cited by 12