Lewis, Peter W.

Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma

Lewis, P. W., Müller, M. M., Koletsky, M. S., Cordero, F., Lin, S., Banaszynski, L. A., Garcia, B. A., Muir, T. W., Becher, O. J., & Allis, C. D. (2013) · Science

Glioma Diagnosis and TreatmentEpigenetics and DNA Methylation

Cited by 1,345

Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation

Funato, K., Major, T., Lewis, P. W., Allis, C. D., & Tabar, V. (2014) · Science

Glioma Diagnosis and TreatmentChromatin Remodeling and Cancer

Cited by 390

Strategy for “Detoxification” of a Cancer-Derived Histone Mutant Based on Mapping Its Interaction with the Methyltransferase PRC2

Brown, Z. Z., Müller, M. M., Jain, S. U., Allis, C. D., Lewis, P. W., & Muir, T. W. (2014) · Journal of the American Chemical Society

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 111

S -adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3

Jayaram, H., Hoelper, D., Jain, S. U., Cantone, N., Lundgren, S. M., Poy, F., Allis, C. D., Cummings, R., Bellon, S., & Lewis, P. W. (2016) · Proceedings of the National Academy of Sciences

Cancer-related gene regulationGenomics and Chromatin Dynamics

Cited by 92

Poisoning the “histone code” in pediatric gliomagenesis

Lewis, P. W., & Allis, C. D. (2013) · Cell Cycle

Glioma Diagnosis and TreatmentChromatin Remodeling and Cancer

Cited by 30

Interplay between Two Paralogous Human Silencing Hub (HuSH) Complexes in Regulating LINE-1 Element Silencing

Jensvold, Z. D., Flood, J. R., Christenson, A. E., & Lewis, P. W. (2024) · Nature Communications

Chromosomal and Genetic VariationsGenomics and Chromatin Dynamics

Cited by 22

Targeted Histone Peptides: Insights into the Spatial Regulation of the Methyltransferase PRC2 by using a Surrogate of Heterotypic Chromatin

Brown, Z. Z., Müller, M. M., Kong, H. E., Lewis, P. W., & Muir, T. W. (2015) · Angewandte Chemie International Edition

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 17