Cooper, Matthew A.

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Coll, R. C., Robertson, A. A. B., Chae, J. J., Higgins, S. C., Muñoz-Planillo, R., Inserra, M. C., Vetter, I., Dungan, L. S., Monks, B. G., Stutz, A., et al. (2015) · Nature Medicine

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 2,849

Emerging Pathogenic Links Between Microbiota and the Gut-Lung Axis

Budden, K. F., Gellatly, S. L., Wood, D. L. A., Cooper, M. A., Morrison, M., Hugenholtz, P., & Hansbro, P. M. (2017) · Nature Reviews Microbiology

Gut microbiota and healthOral microbiology and periodontitis research

Cited by 1,606

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

Fuster, J. J., MacLauchlan, S., Zuriaga, M. A., Polackal, M. N., Ostriker, A. C., Chakraborty, R., Wu, C.-L., Sano, S., Muralidharan, S., Rius, C., et al. (2017) · Science

Atherosclerosis and Cardiovascular DiseasesAcute Myeloid Leukemia Research

Cited by 1,536

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

Mridha, A. R., Wree, A., Robertson, A. A. B., Yeh, M. M., Johnson, C. D., Van Rooyen, D. M., Haczeyni, F., Teoh, N. C.-H., Savard, C., Ioannou, G. N., et al. (2017) · Journal of Hepatology

Liver Disease Diagnosis and TreatmentInflammasome and immune disorders

Cited by 1,110

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

Gordon, R., Albornoz, E. A., Christie, D. C., Langley, M. R., Kumar, V., Mantovani, S., Robertson, A. A. B., Butler, M. S., Rowe, D. B., O’Neill, L. A., et al. (2018) · Science Translational Medicine

Parkinson's Disease Mechanisms and TreatmentsInflammasome and immune disorders

Cited by 897

Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome

Sano, S., Oshima, K., Wang, Y., MacLauchlan, S., Katanasaka, Y., Sano, M., Zuriaga, M. A., Yoshiyama, M., Goukassian, D., Cooper, M. A., et al. (2018) · Journal of the American College of Cardiology

Cardiac Fibrosis and RemodelingAcute Myeloid Leukemia Research

Cited by 699

Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice

Dempsey, C., Rubio Araiz, A., Bryson, K. J., Finucane, O., Larkin, C., Mills, E. L., Robertson, A. A. B., Cooper, M. A., O'Neill, L. A. J., & Lynch, M. A. (2017) · Brain Behavior and Immunity

Inflammasome and immune disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 571

The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins

Deora, V., Lee, J. D., Albornoz, E. A., McAlary, L., Jagaraj, C. J., Robertson, A. A. B., Atkin, J. D., Cooper, M. A., Schroder, K., Yerbury, J. J., et al. (2020) · Glia

Inflammasome and immune disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 245

TET2-loss-of-function-driven clonal hematopoiesis exacerbates experimental insulin resistance in aging and obesity

Fuster, J. J., Zuriaga, M. A., Zorita, V., MacLauchlan, S., Polackal, M. N., Viana-Huete, V., Ferrer-Pérez, A., Matesanz, N., Herrero-Cervera, A., Sano, S., et al. (2020) · Cell Reports

Adipokines, Inflammation, and Metabolic DiseasesAcute Myeloid Leukemia Research

Cited by 204

The eagle effect and antibiotic-induced persistence: two sides of the same coin?

Prasetyoputri, A., Jarrad, A. M., Cooper, M. A., & Blaskovich, M. A. T. (2019) · Trends in Microbiology

Bacterial Genetics and BiotechnologyAntimicrobial Resistance in Staphylococcus

Cited by 101

In vitro Antimicrobial Activity of Acne Drugs Against Skin-Associated Bacteria

Blaskovich, M. A. T., Elliott, A. G., Kavanagh, A. M., Ramu, S., & Cooper, M. A. (2019) · Scientific Reports

Acne and Rosacea Treatments and EffectsDermatology and Skin Diseases

Cited by 89

The Endoplasmic Reticulum-Mitochondrion Tether ERMES Orchestrates Fungal Immune Evasion, Illuminating Inflammasome Responses to Hyphal Signals

Tucey, T. M., Verma-Gaur, J., Nguyen, J., Hewitt, V. L., Lo, T. L., Shingu-Vazquez, M., Robertson, A. A. B., Hill, J. R., Pettolino, F. A., Beddoe, T., et al. (2016) · mSphere

Inflammasome and immune disordersAntifungal resistance and susceptibility

Cited by 66