Brautigan, David L.

Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation

Chen, J., Martin, B. L., & Brautigan, D. L. (1992) · Science

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 601

Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth

Sangodkar, J., Perl, A., Tohme, R., Kiselar, J., Kastrinsky, D. B., Zaware, N., Izadmehr, S., Mazhar, S., Wiredja, D. D., O’Connor, C. M., et al. (2017) · Journal of Clinical Investigation

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 196

Protein Serine/Threonine Phosphatases: Keys to Unlocking Regulators and Substrates

Brautigan, D. L., & Shenolikar, S. (2018) · Annual Review of Biochemistry

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 191

Selective PP2A enhancement through biased heterotrimer stabilization

Leonard, D., Huang, W., Izadmehr, S., O’Connor, C. M., Wiredja, D. D., Wang, Z., Zaware, N., Chen, Y., Schlatzer, D. M., Kiselar, J., et al. (2020) · Cell

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 176

Discovery and characterization of small molecules that target the GTPase Ral

Yan, C., Liu, D., Li, L., Wempe, M. F., Guin, S., Khanna, M., Meier, J., Hoffman, B., Owens, C., Wysoczynski, C. L., et al. (2014) · Nature

Protein Kinase Regulation and GTPase SignalingComputational Drug Discovery Methods

Cited by 150

Cellular chromium enhances activation of insulin receptor kinase

Wang, H., Kruszewski, A., & Brautigan, D. L. (2005) · Biochemistry

Metabolism, Diabetes, and CancerTrace Elements in Health

Cited by 121

Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit α4

Liu, J., Prickett, T. D., Elliott, E., Meroni, G., & Brautigan, D. L. (2001) · Proceedings of the National Academy of Sciences

Protein Tyrosine PhosphatasesMicrotubule and mitosis dynamics

Cited by 100

Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer

McClinch, K., Avelar, R. A., Callejas, D., Izadmehr, S., Wiredja, D., Perl, A., Sangodkar, J., Kastrinsky, D. B., Schlatzer, D., Cooper, M., et al. (2018) · Cancer Research

Prostate Cancer Treatment and ResearchPI3K/AKT/mTOR signaling in cancer

Cited by 78

Ligand Binding to the Androgen Receptor Induces Conformational Changes That Regulate Phosphatase Interactions

Yang, C.-S., Xin, H.-W., Kelley, J. B., Spencer, A., Brautigan, D. L., & Paschal, B. M. (2007) · Molecular and Cellular Biology

Prostate Cancer Treatment and ResearchEstrogen and related hormone effects

Cited by 55

Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors

O’Connor, C. M., Leonard, D., Wiredja, D., Avelar, R. A., Wang, Z., Schlatzer, D., Bryson, B., Tokala, E., Taylor, S. E., Upadhyay, A., et al. (2020) · Oncogene

Protein Tyrosine PhosphatasesMelanoma and MAPK Pathways

Cited by 48