Gadkar, Kapil

Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates

Yu, Y. J., Atwal, J. K., Zhang, Y., Tong, R. K., Wildsmith, K. R., Tan, C., Bien-Ly, N., Hersom, M., Maloney, J. A., Meilandt, W. J., et al. (2014) · Science Translational Medicine

Barrier Structure and Function StudiesAlzheimer's disease research and treatments

Cited by 371

A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models

van Lengerich, B., Zhan, L., Xia, D., Chan, D., Joy, D., Park, J. I., Tatarakis, D., Calvert, M., Hummel, S., Lianoglou, S., et al. (2023) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 233

Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrier

Barker, S. J., Thayer, M. B., Kim, C., Tatarakis, D., Simon, M. J., Dial, R., Nilewski, L., Wells, R. C., Zhou, Y., Afetian, M., et al. (2024) · Science Translational Medicine

RNA Interference and Gene DeliveryBarrier Structure and Function Studies

Cited by 142

A benchmark for methods in reverse engineering and model discrimination: problem formulation and solutions

Kremling, A., Fischer, S., Gadkar, K., Doyle, F. J., Sauter, T., Bullinger, E., Allgöwer, F., & Gilles, E. D. (2004) · Genome Research

Gene Regulatory Network AnalysisMicrobial Metabolic Engineering and Bioproduction

Cited by 127

A Six‐Stage Workflow for Robust Application of Systems Pharmacology

Gadkar, K., Kirouac, D., Mager, D., van der Graaf, P., & Ramanujan, S. (2016) · CPT: Pharmacometrics & Systems Pharmacology

Computational Drug Discovery MethodsStatistical Methods in Clinical Trials

Cited by 93

Model identification of signal transduction networks from data using a state regulator problem.

Gadkar, K. G., Doyle III, F. J., & Varner, J. (2005) · Systems Biology

Gene Regulatory Network AnalysisControl Systems and Identification

Cited by 75

Transferrin receptor-targeted anti-amyloid antibody enhances brain delivery and mitigates ARIA.

Pizzo, M. E., Plowey, E. D., Khoury, N., Kwan, W., Abettan, J., DeVos, S. L., Discenza, C. B., Earr, T., Joy, D., Lye-Barthel, M., et al. (2025) · Science

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 63

Clinical responses to ERK inhibition in BRAF V600E-mutant colorectal cancer predicted using a computational model

Kirouac, D. C., Schaefer, G., Chan, J., Merchant, M., Orr, C., Huang, S.-M. A., Moffat, J., Liu, L., Gadkar, K., & Ramanujan, S. (2017) · npj Systems Biology and Applications

Colorectal Cancer Treatments and StudiesMelanoma and MAPK Pathways

Cited by 60

Mathematical PKPD and safety model of bispecific TfR/BACE1 antibodies for the optimization of antibody uptake in brain

Gadkar, K., Yadav, D. B., Zuchero, J. Y., Couch, J. A., Kanodia, J., Kenrick, M. K., Atwal, J. K., Dennis, M. S., Prabhu, S., Watts, R. J., et al. (2016) · European Journal of Pharmaceutics and Biopharmaceutics

Barrier Structure and Function StudiesAlzheimer's disease research and treatments

Cited by 52

Widespread brain distribution and activity following i.c.v. infusion of anti‐β‐secretase (BACE1) in nonhuman primates

Yadav, D. B., Maloney, J. A., Wildsmith, K. R., Fuji, R. N., Meilandt, W. J., Solanoy, H., Lu, Y., Peng, K., Wilson, B., Chan, P., et al. (2017) · British Journal of Pharmacology

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 49

A Mechanistic Systems Pharmacology Model for Prediction of LDL Cholesterol Lowering by PCSK9 Antagonism in Human Dyslipidemic Populations

Gadkar, K., Budha, N., Baruch, A., Davis, J. D., Fielder, P., & Ramanujan, S. (2014) · CPT: Pharmacometrics & Systems Pharmacology

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 48

Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation

Ribba, B., Grimm, H., Agoram, B., Davies, M., Gadkar, K., Niederer, S., van Riel, N., Timmis, J., & van der Graaf, P. (2017) · CPT: Pharmacometrics & Systems Pharmacology

Statistical Methods in Clinical TrialsComputational Drug Discovery Methods

Cited by 43

FDA-Industry Scientific Exchange on assessing quantitative systems pharmacology models in clinical drug development: a meeting report, summary of challenges/gaps, and future perspective

Bai, J. P. F., Schmidt, B. J., Gadkar, K. G., Damian, V., Earp, J. C., Friedrich, C., van der Graaf, P. H., Madabushi, R., Musante, C. J., Naik, K., et al. (2021) · The AAPS Journal

Statistical Methods in Clinical TrialsPharmaceutical studies and practices

Cited by 38