Ley, Timothy J.

Clonal diversity of recurrently mutated genes in myelodysplastic syndromes

Walter, M. J., Shen, D., Shao, J., Ding, L., White, B. S., Kandoth, C., Miller, C. A., Niu, B., McLellan, M. D., Dees, N. D., et al. (2013) · Leukemia

Acute Myeloid Leukemia ResearchCancer Genomics and Diagnostics

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CpG island hypermethylation mediated by DNMT3A is a consequence of AML progression

Spencer, D. H., Russler-Germain, D. A., Ketkar, S., Helton, N. M., Lamprecht, T. L., Fulton, R. S., Fronick, C. C., O’Laughlin, M., Heath, S. E., Shinawi, M., et al. (2017) · Cell

Acute Myeloid Leukemia ResearchEpigenetics and DNA Methylation

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A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing

Petti, A. A., Williams, S. R., Miller, C. A., Fiddes, I. T., Srivatsan, S. N., Chen, D. Y., Fronick, C. C., Fulton, R. S., Church, D. M., & Ley, T. J. (2019) · Nature Communications

Acute Myeloid Leukemia ResearchSingle-cell and spatial transcriptomics

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Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies

Cole, C. B., Russler-Germain, D. A., Ketkar, S., Verdoni, A. M., Smith, A. M., Bangert, C. V., Helton, N. M., Guo, M., Klco, J. M., O’Laughlin, S., et al. (2017) · Journal of Clinical Investigation

Acute Myeloid Leukemia ResearchEpigenetics and DNA Methylation

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Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARα

Walter, M. J., Park, J. S., Ries, R. E., Lau, S. K. M., McLellan, M., Jaeger, S., Wilson, R. K., Mardis, E. R., & Ley, T. J. (2005) · Proceedings of the National Academy of Sciences

Retinoids in leukemia and cellular processesAcute Myeloid Leukemia Research

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Remethylation of Dnmt3a −/− hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing

Ketkar, S., Verdoni, A. M., Smith, A. M., Bangert, C. V., Leight, E. R., Chen, D. Y., Brune, M. K., Helton, N. M., Hoock, M., George, D. R., et al. (2020) · Proceedings of the National Academy of Sciences

Acute Myeloid Leukemia ResearchEpigenetics and DNA Methylation

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