Arnold, Eddy

Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA

Jacobo-Molina, A., Ding, J., Nanni, R. G., Clark, A. D., Lu, X., Tantillo, C., Williams, R. L., Kamer, G., Ferris, A. L., Clark, P., et al. (1993) · Proceedings of the National Academy of Sciences

HIV/AIDS drug development and treatmentEnzyme Structure and Function

Cited by 1,115

Synthesis, Activity, and Structural Analysis of Novel α-Hydroxytropolone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H

Chung, S., Himmel, D. M., Jiang, J.-K., Wojtak, K., Bauman, J. D., Rausch, J. W., Wilson, J. A., Beutler, J. A., Thomas, C. J., Arnold, E., et al. (2011) · Journal of Medicinal Chemistry

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 80

Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage

Das, K., Martinez, S. E., Bandwar, R. P., & Arnold, E. (2014) · Nucleic Acids Research

HIV/AIDS drug development and treatmentEnzyme Structure and Function

Cited by 68

Cryo-EM structure of the HIV-1 Pol polyprotein provides insights into virion maturation

Harrison, J. J. E. K., Passos, D. O., Bruhn, J. F., Bauman, J. D., Tuberty, L., DeStefano, J. J., Ruiz, F. X., Lyumkis, D., & Arnold, E. (2022) · Science Advances

HIV Research and TreatmentAdvanced Electron Microscopy Techniques and Applications

Cited by 31

Development of enhanced HIV-1 non-nucleoside reverse transcriptase inhibitors with improved resistance and pharmacokinetic profiles

Wang, Z., Rumrill, S., Kang, D., Guma, S. D., Feng, D., De Clercq, E., Pannecouque, C., Chen, C. H., Arnold, E., Ruiz, F. X., et al. (2025) · Science Advances

HIV/AIDS drug development and treatmentComputational Drug Discovery Methods

Cited by 7