Chu, Li-Fang

Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis

Hou, Z., Zhang, Y., Propson, N. E., Howden, S. E., Chu, L.-F., Sontheimer, E. J., & Thomson, J. A. (2013) · Proceedings of the National Academy of Sciences

CRISPR and Genetic EngineeringPluripotent Stem Cells Research

Cited by 681

Single-cell RNA-seq reveals novel regulators of human embryonic stem cell differentiation to definitive endoderm

Chu, L.-F., Leng, N., Zhang, J., Hou, Z., Mamott, D., Vereide, D. T., Choi, J., Kendziorski, C., Stewart, R., & Thomson, J. A. (2016) · Genome Biology

Pluripotent Stem Cells ResearchDevelopmental Biology and Gene Regulation

Cited by 477

SCnorm: robust normalization of single-cell RNA-seq data

Bacher, R., Chu, L.-F., Leng, N., Gasch, A. P., Thomson, J. A., Stewart, R. M., Newton, M., & Kendziorski, C. (2017) · Nature Methods

Single-cell and spatial transcriptomicsGene expression and cancer classification

Cited by 282

A statistical approach for identifying differential distributions in single-cell RNA-seq experiments

Korthauer, K. D., Chu, L.-F., Newton, M. A., Li, Y., Thomson, J., Stewart, R., & Kendziorski, C. (2016) · Genome Biology

Single-cell and spatial transcriptomicsGene expression and cancer classification

Cited by 273

Network inference with Granger causality ensembles on single-cell transcriptomics

Deshpande, A., Chu, L.-F., Stewart, R., & Gitter, A. (2022) · Cell Reports

Gene Regulatory Network AnalysisSingle-cell and spatial transcriptomics

Cited by 130

Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies

Lee, W.-H., Higuchi, H., Ikeda, S., Macke, E. L., Takimoto, T., Pattnaik, B. R., Liu, C., Chu, L.-F., Siepka, S. M., Krentz, K. J., et al. (2016) · eLife

Mitochondrial Function and PathologyRetinal Development and Disorders

Cited by 52

Rapid changes in chromatin structure during dedifferentiation of primary hepatocytes in vitro

Seirup, M., Sengupta, S., Swanson, S., McIntosh, B. E., Collins, M., Chu, L.-F., Cheng, Z., Gorkin, D. U., Duffin, B., Bolin, J. M., et al. (2022) · Genomics

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Cited by 13