Chapple, J Paul

Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2

Metherell, L. A., Chapple, J. P., Cooray, S., David, A., Becker, C., Rüschendorf, F., Naville, D., Begeot, M., Khoo, B., Nürnberg, P., et al. (2005) · Nature Genetics

Adrenal Hormones and DisordersStress Responses and Cortisol

Cited by 437

Deficiency of ferritin heavy-chain nuclear import in Triple A syndrome implies nuclear oxidative damage as the primary disease mechanism

Storr, H. L., Kind, B., Parfitt, D. A., Chapple, J. P., Lorenz, M., Koehler, K., Huebner, A., & Clark, A. J. L. (2009) · Molecular Endocrinology

Nuclear Structure and FunctionNeurological diseases and metabolism

Cited by 84

The majority of adrenocorticotropin receptor (melanocortin 2 receptor) mutations found in familial glucocorticoid deficiency type 1 lead to defective trafficking of the receptor to the cell surface

Chung, T. T., Webb, T. R., Chan, L. F., Cooray, S. N., Metherell, L. A., King, P. J., Chapple, J. P., & Clark, A. J. L. (2008) · The Journal of Clinical Endocrinology & Metabolism

Adrenal Hormones and DisordersReceptor Mechanisms and Signaling

Cited by 82

The melanocortin 2 receptor accessory protein exists as a homodimer and is essential for the function of the melanocortin 2 receptor in the mouse y1 cell line

Cooray, S. N., Almiro Do Vale, I., Leung, K.-Y., Webb, T. R., Chapple, J. P., Egertová, M., Cheetham, M. E., Elphick, M. R., & Clark, A. J. L. (2008) · Endocrinology

Receptor Mechanisms and SignalingAdrenal Hormones and Disorders

Cited by 73

The primary cilium influences interleukin-1β-induced NFκB signalling by regulating IKK activity

Wann, A. K. T., Chapple, J. P., & Knight, M. M. (2014) · Cellular Signalling

Genetic and Kidney Cyst DiseasesNF-κB Signaling Pathways

Cited by 53

Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium

Wann, A. K., Thompson, C. L., Chapple, J. P., & Knight, M. M. (2013) · Cilia

Genetic and Kidney Cyst DiseasesCystic Fibrosis Research Advances

Cited by 38