Bottelbergs, Astrid

Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice

Peeraer, E., Bottelbergs, A., Van Kolen, K., Stancu, I.-C., Vasconcelos, B., Mahieu, M., Duytschaever, H., Ver Donck, L., Torremans, A., Sluydts, E., et al. (2015) · Neurobiology of Disease

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 214

Diffusion kurtosis imaging allows the early detection and longitudinal follow‐up of amyloid‐β‐induced pathology

Praet, J., Manyakov, N. V., Muchene, L., Mai, Z., Terzopoulos, V., de Backer, S., Torremans, A., Guns, P.-J., Van De Casteele, T., Bottelbergs, A., et al. (2018) · Alzheimer's Research & Therapy

Advanced Neuroimaging Techniques and ApplicationsDementia and Cognitive Impairment Research

Cited by 133

Absence of functional peroxisomes from mouse CNS causes dysmyelination and axon degeneration

Hulshagen, L., Krysko, O., Bottelbergs, A., Huyghe, S., Klein, R., Van Veldhoven, P. P., De Deyn, P. P., D'Hooge, R., Hartmann, D., & Baes, M. (2008) · The Journal of Neuroscience

Metabolism and Genetic DisordersLysosomal Storage Disorders Research

Cited by 115

Emergence of early alterations in network oscillations and functional connectivity in a tau seeding mouse model of Alzheimer’s disease pathology

Ahnaou, A., Moechars, D., Raeymaekers, L., Biermans, R., Manyakov, N. V., Bottelbergs, A., Wintmolders, C., Van Kolen, K., Van De Casteele, T., Kemp, J. A., et al. (2017) · Scientific Reports

Alzheimer's disease research and treatmentsNeural dynamics and brain function

Cited by 98

Structural basis for the oligomerization-facilitated NLRP3 activation

Yu, X., Matico, R. E., Miller, R., Chauhan, D., Van Schoubroeck, B., Grauwen, K., Suarez, J., Pietrak, B., Haloi, N., Yin, Y., et al. (2024) · Nature Communications

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 78

Axonal integrity in the absence of functional peroxisomes from projection neurons and astrocytes

Bottelbergs, A., Verheijden, S., Hulshagen, L., Gutmann, D. H., Goebbels, S., Nave, K., Kassmann, C., & Baes, M. (2010) · Glia

Metabolism and Genetic DisordersHereditary Neurological Disorders

Cited by 78

The NLRP3 inflammasome modulates tau pathology and neurodegeneration in a tauopathy model

Stancu, I. C., Lodder, C., Botella Lucena, P., Vanherle, S., Gutiérrez de Ravé, M., Terwel, D., Bottelbergs, A., & Dewachter, I. (2022) · Glia

Alzheimer's disease research and treatmentsInflammasome and immune disorders

Cited by 72

Peroxisome deficiency but not the defect in ether lipid synthesis causes activation of the innate immune system and axonal loss in the central nervous system

Bottelbergs, A., Verheijden, S., Van Veldhoven, P. P., Just, W., Devos, R., & Baes, M. (2012) · Journal of Neuroinflammation

Neuroinflammation and Neurodegeneration MechanismsLysosomal Storage Disorders Research

Cited by 66

Peroxisomal multifunctional protein-2 deficiency causes neuroinflammation and degeneration of Purkinje cells independent of very long chain fatty acid accumulation

Verheijden, S., Bottelbergs, A., Krysko, O., Krysko, D. V., Beckers, L., De Munter, S., Van Veldhoven, P. P., Wyns, S., Kulik, W., Nave, K.-A., et al. (2013) · Neurobiology of Disease

Metabolism and Genetic DisordersGenetic Neurodegenerative Diseases

Cited by 54

Combined deficiency of peroxisomal β-oxidation and ether lipid synthesis in mice causes only minor cortical neuronal migration defects but severe hypotonia

Krysko, O., Bottelbergs, A., Veldhoven, P. V., & Baes, M. (2010) · Molecular Genetics and Metabolism

Metabolism and Genetic DisordersLysosomal Storage Disorders Research

Cited by 17