Lyumkis, Dmitry

Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d

Zhang, C., Konermann, S., Brideau, N. J., Lotfy, P., Wu, X., Novick, S. J., Strutzenberg, T., Griffin, P. R., Hsu, P. D., & Lyumkis, D. (2018) · Cell

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 276

Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome

Passos, D. O., Li, M., Yang, R., Rebensburg, S. V., Ghirlando, R., Jeon, Y., Shkriabai, N., Kvaratskhelia, M., Craigie, R., & Lyumkis, D. (2017) · Science

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 202

Structural basis for strand-transfer inhibitor binding to HIV intasomes

Passos, D. O., Li, M., Jóźwik, I. K., Zhao, X. Z., Santos-Martins, D., Yang, R., Smith, S. J., Jeon, Y., Forli, S., Hughes, S. H., et al. (2020) · Science

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 106

Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function

Ballandras-Colas, A., Brown, M., Cook, N. J., Dewdney, T. G., Demeler, B., Cherepanov, P., Lyumkis, D., & Engelman, A. N. (2016) · Nature

Virus-based gene therapy researchHIV Research and Treatment

Cited by 98

HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors

Koneru, P. C., Francis, A. C., Deng, N., Rebensburg, S. V., Hoyte, A. C., Lindenberger, J., Adu-Ampratwum, D., Larue, R. C., Wempe, M. F., Engelman, A. N., et al. (2019) · eLife

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 49

Cryo-EM structure of the HIV-1 Pol polyprotein provides insights into virion maturation

Harrison, J. J. E. K., Passos, D. O., Bruhn, J. F., Bauman, J. D., Tuberty, L., DeStefano, J. J., Ruiz, F. X., Lyumkis, D., & Arnold, E. (2022) · Science Advances

HIV Research and TreatmentAdvanced Electron Microscopy Techniques and Applications

Cited by 31