Naldini, Luigi

Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming

Bénéchet, A. P., De Simone, G., Di Lucia, P., Cilenti, F., Barbiera, G., Le Bert, N., Fumagalli, V., Lusito, E., Moalli, F., Bianchessi, V., et al. (2019) · Nature

Hepatitis B Virus StudiesT-cell and B-cell Immunology

Cited by 222

Genotoxic effects of base and prime editing in human hematopoietic stem cells

Fiumara, M., Ferrari, S., Omer-Javed, A., Beretta, S., Albano, L., Canarutto, D., Varesi, A., Gaddoni, C., Brombin, C., Cugnata, F., et al. (2024) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 220

Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of SCID-X1

Schiroli, G., Ferrari, S., Conway, A., Jacob, A., Capo, V., Albano, L., Plati, T., Castiello, M. C., Sanvito, F., Gennery, A. R., et al. (2017) · Science Translational Medicine

Virus-based gene therapy researchCRISPR and Genetic Engineering

Cited by 214

Attenuation of miR-126 Activity Expands HSC In Vivo without Exhaustion

Lechman, E. R., Gentner, B., van Galen, P., Giustacchini, A., Saini, M., Boccalatte, F. E., Hiramatsu, H., Restuccia, U., Bachi, A., Voisin, V., et al. (2012) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationMicroRNA in disease regulation

Cited by 208

Uncovering and Dissecting the Genotoxicity of Self-inactivating Lentiviral Vectors In Vivo

Cesana, D., Ranzani, M., Volpin, M., Bartholomae, C., Duros, C., Artus, A., Merella, S., Benedicenti, F., Sergi Sergi, L., Sanvito, F., et al. (2014) · Molecular Therapy

Virus-based gene therapy researchCRISPR and Genetic Engineering

Cited by 189

Liver-directed lentiviral gene therapy in a dog model of hemophilia B

Cantore, A., Ranzani, M., Bartholomae, C. C., Volpin, M., Valle, P. D., Sanvito, F., Sergi, L. S., Gallina, P., Benedicenti, F., Bellinger, D., et al. (2015) · Science Translational Medicine

Virus-based gene therapy researchHemophilia Treatment and Research

Cited by 158

Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk

Mátrai, J., Cantore, A., Bartholomae, C. C., Annoni, A., Wang, W., Acosta-Sanchez, A., Samara-Kuko, E., De Waele, L., Ma, L., Genovese, P., et al. (2011) · Hepatology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 139

Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells

Ferrari, S., Jacob, A., Cesana, D., Laugel, M., Beretta, S., Varesi, A., Unali, G., Conti, A., Canarutto, D., Albano, L., et al. (2022) · Cell stem cell

Virus-based gene therapy researchCRISPR and Genetic Engineering

Cited by 133

Hyperfunctional coagulation factor IX improves the efficacy of gene therapy in hemophilic mice

Cantore, A., Nair, N., Della Valle, P., Di Matteo, M., Màtrai, J., Sanvito, F., Brombin, C., Di Serio, C., D'Angelo, A., Chuah, M., et al. (2012) · Blood

Hemophilia Treatment and ResearchVirus-based gene therapy research

Cited by 101

Lentiviral vectors escape innate sensing but trigger p53 in human hematopoietic stem and progenitor cells

Piras, F., Riba, M., Petrillo, C., Lazarevic, D., Cuccovillo, I., Bartolaccini, S., Stupka, E., Gentner, B., Cittaro, D., Naldini, L., et al. (2017) · EMBO Molecular Medicine

Virus-based gene therapy researchHematopoietic Stem Cell Transplantation

Cited by 75

Genome editing for scalable production of alloantigen‐free lentiviral vectors for in vivo gene therapy

Milani, M., Annoni, A., Bartolaccini, S., Biffi, M., Russo, F., Di Tomaso, T., Raimondi, A., Lengler, J., Holmes, M. C., Scheiflinger, F., et al. (2017) · EMBO Molecular Medicine

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 72

Reprogramming T Lymphocytes for Melanoma Adoptive Immunotherapy by T-Cell Receptor Gene Transfer with Lentiviral Vectors

Bobisse, S., Rondina, M., Merlo, A., Tisato, V., Mandruzzato, S., Amendola, M., Naldini, L., Willemsen, R. A., Debets, R., Zanovello, P., et al. (2009) · Cancer Research

Virus-based gene therapy researchImmunotherapy and Immune Responses

Cited by 62

Lentiviral Vector-based Insertional Mutagenesis Identifies Genes Involved in the Resistance to Targeted Anticancer Therapies

Ranzani, M., Annunziato, S., Calabria, A., Brasca, S., Benedicenti, F., Gallina, P., Naldini, L., & Montini, E. (2014) · Molecular Therapy

Virus-based gene therapy researchLung Cancer Treatments and Mutations

Cited by 17