Smith, Matthew J.

Inhibition of RAS function through targeting an allosteric regulatory site

Spencer-Smith, R., Koide, A., Zhou, Y., Eguchi, R. R., Sha, F., Gajwani, P., Santana, D., Gupta, A., Jacobs, M., Herrero-Garcia, E., et al. (2017) · Nature Chemical Biology

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 283

NMR-based functional profiling of RASopathies and oncogenic RAS mutations

Smith, M. J., Neel, B. G., & Ikura, M. (2013) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 257

Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site

Mazhab-Jafari, M. T., Marshall, C. B., Smith, M. J., Gasmi-Seabrook, G. M. C., Stathopulos, P. B., Inagaki, F., Kay, L. E., Neel, B. G., & Ikura, M. (2015) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingLipid Membrane Structure and Behavior

Cited by 220

Integrated RAS signaling defined by parallel NMR detection of effectors and regulators

Smith, M. J., & Ikura, M. (2014) · Nature Chemical Biology

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 87

Structure of the DOCK2−ELMO1 complex provides insights into regulation of the auto-inhibited state

Chang, L., Yang, J., Jo, C. H., Boland, A., Zhang, Z., McLaughlin, S. H., Abu-Thuraia, A., Killoran, R. C., Smith, M. J., Côté, J.-F., et al. (2020) · Nature Communications

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 59

Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts

Marshall, C. B., Meiri, D., Smith, M. J., Mazhab-Jafari, M. T., Gasmi-Seabrook, G. M. C., Rottapel, R., Stambolic, V., & Ikura, M. (2012) · Methods

Protein Kinase Regulation and GTPase SignalingAdvanced NMR Techniques and Applications

Cited by 46