Lepack, Ashley E.

Decreased expression of synapse-related genes and loss of synapses in major depressive disorder

Kang, H. J., Voleti, B., Hajszan, T., Rajkowska, G., Stockmeier, C. A., Licznerski, P., Lepack, A., Majik, M. S., Jeong, L. S., Banasr, M., et al. (2012) · Nature Medicine

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 808

BDNF release is required for the behavioral actions of ketamine

Lepack, A. E., Fuchikami, M., Dwyer, J. M., Banasr, M., & Duman, R. S. (2015) · International Journal of Neuropsychopharmacology

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 368

GSK-3 inhibition potentiates the synaptogenic and antidepressant-like effects of subthreshold doses of ketamine

Liu, R.-J., Fuchikami, M., Dwyer, J. M., Lepack, A. E., Duman, R. S., & Aghajanian, G. K. (2013) · Neuropsychopharmacology

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 256

Fast-Acting Antidepressants Rapidly Stimulate ERK Signaling and BDNF Release in Primary Neuronal Cultures

Lepack, A. E., Bang, E., Lee, B., Dwyer, J. M., & Duman, R. S. (2016) · Neuropharmacology

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 174

mTOR activation is required for the antidepressant effects of mGluR2/3 blockade

Dwyer, J. M., Lepack, A. E., & Duman, R. S. (2012) · The International Journal of Neuropsychopharmacology

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 169

Characterization of GABAergic Marker Expression in the Chronic Unpredictable Stress Model of Depression

Banasr, M., Lepack, A., Fee, C., Duric, V., Maldonado-Aviles, J., DiLeone, R., Sibille, E., Duman, R. S., & Sanacora, G. (2017) · Chronic Stress

Neuroscience and Neuropharmacology ResearchStress Responses and Cortisol

Cited by 135

Rapid antidepressant actions of scopolamine: Role of medial prefrontal cortex and M1-subtype muscarinic acetylcholine receptors

Navarria, A., Wohleb, E. S., Voleti, B., Ota, K. T., Dutheil, S., Lepack, A. E., Dwyer, J. M., Fuchikami, M., Becker, A., Drago, F., et al. (2015) · Neurobiology of Disease

Treatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

Cited by 118

Activity-Dependent Brain-Derived Neurotrophic Factor Release Is Required for the Rapid Antidepressant Actions of Scopolamine

Ghosal, S., Bang, E., Yue, W., Hare, B. D., Lepack, A. E., Girgenti, M. J., & Duman, R. S. (2018) · Biological Psychiatry

Treatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

Cited by 111

Neuritin produces antidepressant actions and blocks the neuronal and behavioral deficits caused by chronic stress

Son, H., Banasr, M., Choi, M., Chae, S. Y., Licznerski, P., Lee, B., Voleti, B., Li, N., Lepack, A., Fournier, N. M., et al. (2012) · Proceedings of the National Academy of Sciences

Treatment of Major DepressionStress Responses and Cortisol

Cited by 103

mGluR2/3 blockade produces rapid and long-lasting reversal of anhedonia caused by chronic stress exposure

Dwyer, J. M., Lepack, A. E., & Duman, R. S. (2013) · Journal of Molecular Psychiatry

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 81

Ribosomal protein S6 kinase 1 signaling in prefrontal cortex controls depressive behavior

Dwyer, J. M., Maldonado-Avilés, J. G., Lepack, A. E., DiLeone, R. J., & Duman, R. S. (2015) · Proceedings of the National Academy of Sciences

Treatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

Cited by 76

Cell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility

Heshmati, M., Aleyasin, H., Menard, C., Christoffel, D. J., Flanigan, M. E., Pfau, M. L., Hodes, G. E., Lepack, A. E., Bicks, L. K., Takahashi, A., et al. (2018) · Proceedings of the National Academy of Sciences

Neurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

Cited by 75

Aberrant H3.3 dynamics in NAc promote vulnerability to depressive-like behavior

Lepack, A. E., Bagot, R. C., Peña, C. J., Loh, Y.-H. E., Farrelly, L. A., Lu, Y., Powell, S. K., Lorsch, Z. S., Issler, O., Cates, H. M., et al. (2016) · Proceedings of the National Academy of Sciences

Genomics and Chromatin DynamicsTreatment of Major Depression

Cited by 63