Pennington, Michael W.

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease

Rangaraju, S., Dammer, E. B., Raza, S. A., Rathakrishnan, P., Xiao, H., Gao, T., Duong, D. M., Pennington, M. W., Lah, J. J., Seyfried, N. T., et al. (2018) · Molecular Neurodegeneration

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 430

Durable Pharmacological Responses from the Peptide ShK-186, a Specific Kv1.3 Channel Inhibitor That Suppresses T Cell Mediators of Autoimmune Disease

Tarcha, E. J., Chi, V., Muñoz-Elías, E. J., Bailey, D., Londono, L. M., Upadhyay, S. K., Norton, K., Banks, A., Tjong, I., Nguyen, H., et al. (2012) · The Journal of Pharmacology and Experimental Therapeutics

Ion channel regulation and functionT-cell and B-cell Immunology

Cited by 117

Kv1.3 potassium channels as a therapeutic target in multiple sclerosis

Rangaraju, S., Chi, V., Pennington, M. W., & Chandy, K. G. (2009) · Expert Opinion on Therapeutic Targets

Ion channel regulation and functionMultiple Sclerosis Research Studies

Cited by 99

Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases

Chhabra, S., Chang, S. C., Nguyen, H. M., Huq, R., Tanner, M. R., Londono, L. M., Estrada, R., Dhawan, V., Chauhan, S., Upadhyay, S. K., et al. (2014) · The FASEB Journal

Parasites and Host InteractionsIon channel regulation and function

Cited by 91

A Novel Fluorescent Toxin to Detect and Investigate Kv1.3 Channel Up-regulation in Chronically Activated T Lymphocytes

Beeton, C., Wulff, H., Singh, S., Botsko, S., Crossley, G., Gutman, G. A., Cahalan, M. D., Pennington, M., & Chandy, K. G. (2003) · Journal of Biological Chemistry

Ion channel regulation and functionIon Channels and Receptors

Cited by 90

Blockade of Kv1.3 channels ameliorates radiation-induced brain injury

Peng, Y., Lu, K., Li, Z., Zhao, Y., Wang, Y., Hu, B., Xu, P., Shi, X., Zhou, B., Pennington, M., et al. (2014) · Neuro-Oncology

Effects of Radiation ExposureNeuroinflammation and Neurodegeneration Mechanisms

Cited by 78

A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation

Rangaraju, S., Raza, S. A., Pennati, A., Deng, Q., Dammer, E. B., Duong, D., Pennington, M. W., Tansey, M. G., Lah, J. J., Betarbet, R., et al. (2017) · Journal of Neuroinflammation

Neuroinflammation and Neurodegeneration MechanismsIon channel regulation and function

Cited by 75

Development of Highly Selective Kv1.3-Blocking Peptides Based on the Sea Anemone Peptide ShK

Pennington, M., Chang, S., Chauhan, S., Huq, R., Tajhya, R., Chhabra, S., Norton, R., & Beeton, C. (2015) · Marine Drugs

Ion channel regulation and functionChemical Synthesis and Analysis

Cited by 70

The molecular evolution of feathers with direct evidence from fossils

Pan, Y., Zheng, W., Sawyer, R. H., Pennington, M. W., Zheng, X., Wang, X., Wang, M., Hu, L., O’Connor, J., Zhao, T., et al. (2019) · Proceedings of the National Academy of Sciences

Paleontology and Evolutionary BiologyFossil Insects in Amber

Cited by 67