Chang, Jianhui

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

Chang, J., Wang, Y., Shao, L., Laberge, R.-M., Demaria, M., Campisi, J., Janakiraman, K., Sharpless, N. E., Ding, S., Feng, W., et al. (2016) · Nature Medicine

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,819

Cellular senescence promotes adverse effects of chemotherapy and cancer relapse

Demaria, M., O'Leary, M. N., Chang, J., Shao, L., Liu, S., Alimirah, F., Koenig, K., Le, C., Mitin, N., Deal, A. M., et al. (2017) · Cancer Discovery

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,338

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

He, Y., Zhang, X., Chang, J., Kim, H.-N., Zhang, P., Wang, Y., Khan, S., Liu, X., Zhang, X., Lv, D., et al. (2020) · Nature Communications

Protein Degradation and InhibitorsTelomeres, Telomerase, and Senescence

Cited by 280

Discovery of piperlongumine as a potential novel lead for the development of senolytic agents

Wang, Y., Chang, J., Liu, X., Zhang, X., Zhang, S., Zhang, X., Zhou, D., & Zheng, G. (2016) · Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 274

DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age

Kim, H., Chang, J., Shao, L., Han, L., Iyer, S., Manolagas, S. C., O'Brien, C. A., Jilka, R. L., Zhou, D., & Almeida, M. (2017) · Aging Cell

Bone Metabolism and DiseasesTelomeres, Telomerase, and Senescence

Cited by 192

Oxidation resistance 1 is a novel senolytic target

Zhang, X., Zhang, S., Liu, X., Wang, Y., Chang, J., Zhang, X., Mackintosh, S. G., Tackett, A. J., He, Y., Lv, D., et al. (2018) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 127

Elimination of senescent osteoclast progenitors has no effect on the age‐associated loss of bone mass in mice

Kim, H., Chang, J., Iyer, S., Han, L., Campisi, J., Manolagas, S. C., Zhou, D., & Almeida, M. (2019) · Aging Cell

Bone Metabolism and DiseasesTelomeres, Telomerase, and Senescence

Cited by 74

Mitigation of ionizing radiation-induced bone marrow suppression by p38 inhibition and G-CSF administration.

LI, D., WANG, Y., WU, H., LU, L., ZHANG, H., CHANG, J., ZHAI, Z., ZHANG, J., WANG, Y., ZHOU, D., et al. (2011) · Journal of Radiation Research

Effects of Radiation ExposureHematopoietic Stem Cell Transplantation

Cited by 28

The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow

Shao, L., Chang, J., Feng, W., Wang, X., Williamson, E. A., Li, Y., Schajnovitz, A., Scadden, D., Mortensen, L. J., Lin, C. P., et al. (2018) · Nature Communications

Hematopoietic Stem Cell TransplantationBlood disorders and treatments

Cited by 20