Imlay, James A.

DNA damage and oxygen radical toxicity

Imlay, J. A., & Linn, S. (1988) · Science

Redox biology and oxidative stressMetal-Catalyzed Oxygenation Mechanisms

Cited by 1,974

Cellular Defenses against Superoxide and Hydrogen Peroxide

Imlay, J. A. (2008) · Annual Review of Biochemistry

Redox biology and oxidative stressMetal-Catalyzed Oxygenation Mechanisms

Cited by 1,563

Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro

Imlay, J. A., Chin, S. M., & Linn, S. (1988) · Science

Redox biology and oxidative stressMetal-Catalyzed Oxygenation Mechanisms

Cited by 1,555

The iron-sulfur clusters of dehydratases are primary intracellular targets of copper toxicity

Macomber, L., & Imlay, J. A. (2009) · Proceedings of the National Academy of Sciences

Metalloenzymes and iron-sulfur proteinsTrace Elements in Health

Cited by 1,117

Superoxide accelerates DNA damage by elevating free-iron levels

Keyer, K., & Imlay, J. A. (1996) · Proceedings of the National Academy of Sciences

Redox biology and oxidative stressMetal-Catalyzed Oxygenation Mechanisms

Cited by 841

Intracellular Copper Does Not Catalyze the Formation of Oxidative DNA Damage in Escherichia coli

Macomber, L., Rensing, C., & Imlay, J. A. (2007) · Journal of Bacteriology

Bacterial Genetics and BiotechnologyRedox biology and oxidative stress

Cited by 356

Manganese import is a key element of the OxyR response to hydrogen peroxide in Escherichia coli

Anjem, A., Varghese, S., & Imlay, J. A. (2009) · Molecular Microbiology

Redox biology and oxidative stressBacterial Genetics and Biotechnology

Cited by 324

When anaerobes encounter oxygen: mechanisms of oxygen toxicity, tolerance and defence

Lu, Z., & Imlay, J. A. (2021) · Nature Reviews Microbiology

Redox biology and oxidative stressBacterial Genetics and Biotechnology

Cited by 318

Mechanism of superoxide and hydrogen peroxide formation by fumarate reductase, succinate dehydrogenase, and aspartate oxidase

Messner, K. R., & Imlay, J. A. (2002) · Journal of Biological Chemistry

Redox biology and oxidative stressMetal-Catalyzed Oxygenation Mechanisms

Cited by 301

Mitochondrial iron detoxification is a primary function of frataxin that limits oxidative damage and preserves cell longevity

Gakh, O., Park, S., Liu, G., Macomber, L., Imlay, J. A., Ferreira, G. C., & Isaya, G. (2006) · Human Molecular Genetics

Mitochondrial Function and PathologyGenetic Neurodegenerative Diseases

Cited by 184

Reduced Flavins Promote Oxidative DNA Damage in Non-respiringEscherichia coli by Delivering Electrons to Intracellular Free Iron

Woodmansee, A. N., & Imlay, J. A. (2002) · Journal of Biological Chemistry

Redox biology and oxidative stressBacterial Genetics and Biotechnology

Cited by 152

Yeast lacking superoxide dismutase (s) show elevated levels of “free iron” as measured by whole cell electron paramagnetic resonance

Srinivasan, C., Liba, A., Imlay, J. A., Valentine, J. S., & Gralla, E. B. (2000) · Journal of Biological Chemistry

Redox biology and oxidative stressMetal-Catalyzed Oxygenation Mechanisms

Cited by 134

Submicromolar hydrogen peroxide disrupts the ability of Fur protein to control free‐iron levels in Escherichia coli

Varghese, S., Wu, A., Park, S., Imlay, K. R. C., & Imlay, J. A. (2007) · Molecular Microbiology

Bacterial Genetics and BiotechnologyRedox biology and oxidative stress

Cited by 133

The induction of two biosynthetic enzymes helps Escherichia coli sustain heme synthesis and activate catalase during hydrogen peroxide stress

Mancini, S., & Imlay, J. A. (2015) · Molecular Microbiology

Bacterial Genetics and BiotechnologyRedox biology and oxidative stress

Cited by 66

A Salmonella enterica Serovar Typhimurium hemA Mutant Is Highly Susceptible to Oxidative DNA Damage

Elgrably-Weiss, M., Park, S., Schlosser-Silverman, E., Rosenshine, I., Imlay, J., & Altuvia, S. (2002) · Journal of Bacteriology

Bacterial Genetics and BiotechnologyRedox biology and oxidative stress

Cited by 39

How a natural antibiotic uses oxidative stress to kill oxidant-resistant bacteria

Gupta, A., & Imlay, J. A. (2023) · Proceedings of the National Academy of Sciences

Bioactive Compounds and Antitumor AgentsRedox biology and oxidative stress

Cited by 34

During Oxidative Stress the Clp Proteins of Escherichia coli Ensure that Iron Pools Remain Sufficient To Reactivate Oxidized Metalloenzymes

Sen, A., Zhou, Y., & Imlay, J. A. (2020) · Journal of Bacteriology

Bacterial Genetics and BiotechnologyRedox biology and oxidative stress

Cited by 24

Microbes vary strategically in their metalation of mononuclear enzymes

Rohaun, S. K., Sethu, R., & Imlay, J. A. (2024) · Proceedings of the National Academy of Sciences

Metal-Catalyzed Oxygenation MechanismsRedox biology and oxidative stress

Cited by 11