Macartney, Thomas

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

Kondapalli, C., Kazlauskaite, A., Zhang, N., Woodroof, H. I., Campbell, D. G., Gourlay, R., Burchell, L., Walden, H., Macartney, T. J., Deak, M., et al. (2012) · Open Biology

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

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Identification of the MMS22L-TONSL Complex that Promotes Homologous Recombination

Duro, E., Lundin, C., Ask, K., Sanchez-Pulido, L., MacArtney, T. J., Toth, R., Ponting, C. P., Groth, A., Helleday, T., & Rouse, J. (2010) · Molecular Cell

DNA Repair MechanismsFungal and yeast genetics research

Cited by 125

An affinity-directed protein missile system for targeted proteolysis

Fulcher, L. J., Macartney, T., Bozatzi, P., Hornberger, A., Rojas-Fernandez, A., & Sapkota, G. P. (2016) · Open Biology

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 91

Targeting endogenous proteins for degradation through the affinity-directed protein missile system

Fulcher, L. J., Hutchinson, L. D., Macartney, T. J., Turnbull, C., & Sapkota, G. P. (2017) · Open Biology

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 79

Phosphorylation of synaptic vesicle protein 2A at Thr84 by casein kinase 1 family kinases controls the specific retrieval of synaptotagmin-1

Zhang, N., Gordon, S. L., Fritsch, M. J., Esoof, N., Campbell, D. G., Gourlay, R., Velupillai, S., Macartney, T., Peggie, M., van Aalten, D. M. F., et al. (2015) · The Journal of Neuroscience

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 72

Human UFSP1 is an active protease that regulates UFM1 maturation and UFMylation

Millrine, D., Cummings, T., Matthews, S. P., Peter, J. J., Magnussen, H. M., Lange, S. M., Macartney, T., Lamoliatte, F., Knebel, A., & Kulathu, Y. (2022) · Cell Reports

Ubiquitin and proteasome pathwaysCancer-related gene regulation

Cited by 71

Human UFSP1 is an active protease that regulates UFM1 maturation and UFMylation

Millrine, D., Cummings, T., Matthews, S. P., Peter, J. J., Magnussen, H., Macartney, T., Lamoliatte, F., Knebel, A., & Kulathu, Y. (2022) · Cell Reports

Ubiquitin and proteasome pathwaysCancer-related gene regulation

Cited by 71

Mapping of a N-terminal α-helix domain required for human PINK1 stabilization, Serine228 autophosphorylation and activation in cells

Kakade, P., Ojha, H., Raimi, O. G., Shaw, A., Waddell, A. D., Ault, J. R., Burel, S., Brockmann, K., Kumar, A., Ahangar, M. S., et al. (2022) · Open Biology

Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy

Cited by 42

Parkinson’s VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B

Pal, P., Taylor, M., Lam, P. Y., Tonelli, F., Hecht, C. A., Lis, P., Nirujogi, R. S., Phung, T. K., Yeshaw, W. M., Jaimon, E., et al. (2023) · Science Advances

Parkinson's Disease Mechanisms and TreatmentsCellular transport and secretion

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Mutations within the predicted fragment-binding region of FAM83G/SACK1G abolish its interaction with the Ser/Thr kinase CK1α

Utgés, J. S., Xuan, D. L. Z., Le Chatelier, B., Glennie, L., Macartney, T. J., Wood, N. T., Barton, G. J., & Sapkota, G. P. (2025) · Open Biology

Wnt/β-catenin signaling in development and cancerProtein Structure and Dynamics

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