Neckers, Len

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

Whitesell, L., Mimnaugh, E. G., De Costa, B., Myers, C. E., & Neckers, L. M. (1994) · Proceedings of the National Academy of Sciences

Heat shock proteins researchProtein Kinase Regulation and GTPase Signaling

Cited by 1,444

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability

Isaacs, J. S., Jung, Y. J., Mole, D. R., Lee, S., Torres-Cabala, C., Chung, Y.-L., Merino, M., Trepel, J., Zbar, B., Toro, J., et al. (2005) · Cancer Cell

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 958

Hsp90 inhibitors as novel cancer chemotherapeutic agents

Neckers, L. (2002) · Trends in Molecular Medicine

Heat shock proteins researchUbiquitin and proteasome pathways

Cited by 677

An Acetylation Site in the Middle Domain of Hsp90 Regulates Chaperone Function

Scroggins, B. T., Robzyk, K., Wang, D., Marcu, M. G., Tsutsumi, S., Beebe, K., Cotter, R. J., Felts, S., Toft, D., Karnitz, L., et al. (2007) · Molecular Cell

Heat shock proteins researchUbiquitin and proteasome pathways

Cited by 413

Update on Hsp90 Inhibitors in Clinical Trial

Kim, Y., Alarcon, S., Lee, S., Lee, M.-J., Giaccone, G., Neckers, L., & Trepel, J. (2009) · Current Topics in Medicinal Chemistry

Heat shock proteins researchProtein Degradation and Inhibitors

Cited by 311

Post-translational modifications of Hsp90 and their contributions to chaperone regulation

Mollapour, M., & Neckers, L. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Heat shock proteins researchUbiquitin and proteasome pathways

Cited by 288

Fumarate Hydratase Deficiency in Renal Cancer Induces Glycolytic Addiction and Hypoxia-Inducible Transcription Factor 1α Stabilization by Glucose-Dependent Generation of Reactive Oxygen Species

Sudarshan, S., Sourbier, C., Kong, H.-S., Block, K., Romero, V. A. V., Yang, Y., Galindo, C., Mollapour, M., Scroggins, B., Goode, N., et al. (2009) · Molecular and Cellular Biology

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 217

Swe1Wee1-Dependent Tyrosine Phosphorylation of Hsp90 Regulates Distinct Facets of Chaperone Function

Mollapour, M., Tsutsumi, S., Donnelly, A. C., Beebe, K., Tokita, M. J., Lee, M.-J., Lee, S., Morra, G., Bourboulia, D., Scroggins, B. T., et al. (2010) · Molecular Cell

Heat shock proteins researchUbiquitin and proteasome pathways

Cited by 196

Threonine 22 Phosphorylation Attenuates Hsp90 Interaction with Cochaperones and Affects Its Chaperone Activity

Mollapour, M., Tsutsumi, S., Truman, A. W., Xu, W., Vaughan, C. K., Beebe, K., Konstantinova, A., Vourganti, S., Panaretou, B., Piper, P. W., et al. (2011) · Molecular Cell

Heat shock proteins researchUbiquitin and proteasome pathways

Cited by 165

Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells

Rasola, A., Neckers, L., & Picard, D. (2014) · Trends in Cell Biology

Cancer, Hypoxia, and MetabolismHeat shock proteins research

Cited by 129

Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity

Mollapour, M., Tsutsumi, S., Kim, Y. S., Trepel, J., & Neckers, L. (2011) · Oncotarget

Heat shock proteins researchUbiquitin and proteasome pathways

Cited by 66

Human T lymphotropic virus I infection deregulates surface expression of the transferrin receptor.

Vidal, C., Matsushita, S., Colamonici, O. R., Trepel, J. B., Mitsuya, H., & Neckers, L. M. (1988) · The Journal of Immunology

T-cell and Retrovirus StudiesIron Metabolism and Disorders

Cited by 12