Billadeau, Daniel D.

Structure and control of the actin regulatory WAVE complex

Chen, Z., Borek, D., Padrick, S. B., Gomez, T. S., Metlagel, Z., Ismail, A. M., Umetani, J., Billadeau, D. D., Otwinowski, Z., & Rosen, M. K. (2010) · Nature

Cellular Mechanics and InteractionsProtein Kinase Regulation and GTPase Signaling

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Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling

McNally, K. E., Faulkner, R., Steinberg, F., Gallon, M., Ghai, R., Pim, D., Langton, P., Pearson, N., Danson, C. M., Nägele, H., et al. (2017) · Nature Cell Biology

Cellular transport and secretionAutophagy in Disease and Therapy

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The WAVE2 Complex Regulates Actin Cytoskeletal Reorganization and CRAC-Mediated Calcium Entry during T Cell Activation

Nolz, J. C., Gomez, T. S., Zhu, P., Li, S., Medeiros, R. B., Shimizu, Y., Burkhardt, J. K., Freedman, B. D., & Billadeau, D. D. (2006) · Current Biology

Protein Kinase Regulation and GTPase SignalingIon Channels and Receptors

Cited by 237

Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial

Liu, P., Leong, T., Quam, L., Billadeau, D., Kay, N., Greipp, P., Kyle, R., Oken, M., & Van Ness, B. (1996) · Blood

Multiple Myeloma Research and TreatmentsChronic Lymphocytic Leukemia Research

Cited by 215

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

Bartuzi, P., Billadeau, D. D., Favier, R., Rong, S., Dekker, D., Fedoseienko, A., Fieten, H., Wijers, M., Levels, J. H., Huijkman, N., et al. (2016) · Nature Communications

Cholesterol and Lipid MetabolismCellular transport and secretion

Cited by 205

Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1

Yu, B., Martins, I. R. S., Li, P., Amarasinghe, G. K., Umetani, J., Fernandez-Zapico, M. E., Billadeau, D. D., Machius, M., Tomchick, D. R., & Rosen, M. K. (2010) · Cell

Protein Kinase Regulation and GTPase SignalingProtein Structure and Dynamics

Cited by 156

The COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking

Fedoseienko, A., Wijers, M., Wolters, J. C., Dekker, D., Smit, M., Huijkman, N., Kloosterhuis, N., Klug, H., Schepers, A., Willems van Dijk, K., et al. (2018) · Circulation Research

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 126

Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling

Singla, A., Fedoseienko, A., Giridharan, S. S. P., Overlee, B. L., Lopez, A., Jia, D., Song, J., Huff-Hardy, K., Weisman, L., Burstein, E., et al. (2019) · Nature Communications

Cellular transport and secretionAutophagy in Disease and Therapy

Cited by 113

Structural organization of the retriever–CCC endosomal recycling complex

Boesch, D. J., Singla, A., Han, Y., Kramer, D. A., Liu, Q., Suzuki, K., Juneja, P., Zhao, X., Long, X., Medlyn, M. J., et al. (2024) · Nature Structural & Molecular Biology

Cellular transport and secretionAutophagy in Disease and Therapy

Cited by 52

Structural Organization of the Retriever-CCC Endosomal Recycling Complex

Boesch, D., Singla, A., Han, Y., Kramer, D., Liu, Q., Suzuki, K., Juneja, P., Zhao, X., Long, X., Medlyn, M., et al. (2023) · Nature Structural & Molecular Biology

Cellular transport and secretionAutophagy in Disease and Therapy

Cited by 51

Structural Organization of the Retriever-CCC Endosomal Recycling Complex

Boesch, D. J., Singla, A., Han, Y., Kramer, D. A., Liu, Q., Suzuki, K., Juneja, P., Zhao, X., Long, X., Medlyn, M. J., et al. (2023) · Nature Structural & Molecular Biology

Cellular transport and secretionAutophagy in Disease and Therapy

Cited by 51

The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance

Wijers, M., Zanoni, P., Liv, N., Vos, D. Y., Jäckstein, M. Y., Smit, M., Wilbrink, S., Wolters, J. C., van der Veen, Y. T., Huijkman, N., et al. (2019) · JCI Insight

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 44

Arf GTPase activates the WAVE regulatory complex through a distinct binding site

Yang, S., Tang, Y., Liu, Y., Brown, A. J., Schaks, M., Ding, B., Kramer, D. A., Mietkowska, M., Ding, L., Alekhina, O., et al. (2022) · Science Advances

Protein Kinase Regulation and GTPase SignalingCellular Mechanics and Interactions

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Structural basis for Retriever-SNX17 assembly and endosomal sorting

Singla, A., Boesch, D. J., Fung, H. Y. J., Ngoka, C., Enriquez, A. S., Song, R., Kramer, D. A., Han, Y., Banarer, E., Lemoff, A., et al. (2024) · Nature Communications

Cellular transport and secretionAutophagy in Disease and Therapy

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CCDC22 mutations that impair COMMD binding cause attenuated 3C/Ritscher-Schinzel syndrome

Singla, A., Rogers, C., Touma, M.-J., El-Najjar, Y., Colley, A., Boesch, D. J., Billadeau, D. D., Gecz, J., Chen, B., & Burstein, E. (2025) · BMC Medical Genomics

Cellular transport and secretionGenomics and Rare Diseases

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