Tycko, Josh

Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements

Mumbach, M. R., Satpathy, A. T., Boyle, E. A., Dai, C., Gowen, B. G., Cho, S. W., Nguyen, M. L., Rubin, A. J., Granja, J. M., Kazane, K. R., et al. (2017) · Nature Genetics

Genomics and Chromatin DynamicsGenetic Associations and Epidemiology

Cited by 490

Methods and Applications of CRISPR-Mediated Base Editing in Eukaryotic Genomes

Hess, G. T., Tycko, J., Yao, D., & Bassik, M. C. (2017) · Molecular Cell

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 234

Lessons learned from the clinical development and market authorization of Glybera

Bryant, L. M., Christopher, D. M., Giles, A. R., Hinderer, C., Rodriguez, J. L., Smith, J. B., Traxler, E. A., Tycko, J., Wojno, A. P., & Wilson, J. M. (2013) · Human Gene Therapy Clinical Development

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 189

Large-scale mapping and mutagenesis of human transcriptional effector domains

DelRosso, N., Tycko, J., Suzuki, P., Andrews, C., Aradhana, Mukund, A., Liongson, I., Ludwig, C., Spees, K., Fordyce, P., et al. (2023) · Nature

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 130

Development of compact transcriptional effectors using high-throughput measurements in diverse contexts

Tycko, J., Van, M. V., Aradhana, DelRosso, N., Ye, H., Yao, D., Valbuena, R., Vaughan-Jackson, A., Xu, X., Ludwig, C., et al. (2025) · Nature Biotechnology

CRISPR and Genetic EngineeringGenomics and Chromatin Dynamics

Cited by 57