Sheffler, William

Broadly applicable and accurate protein design by integrating structure prediction networks and diffusion generative models

Watson, J. L., Juergens, D., Bennett, N. R., Trippe, B. L., Yim, J., Eisenach, H. E., Ahern, W., Borst, A. J., Ragotte, R. J., Milles, L. F., et al. (2022) · Nature

Protein Structure and DynamicsMachine Learning in Bioinformatics

Cited by 2,369

De novo design of protein structure and function with RFdiffusion

Watson, J. L., Juergens, D., Bennett, N. R., Trippe, B. L., Yim, J., Eisenach, H. E., Ahern, W., Borst, A. J., Ragotte, R. J., Milles, L. F., et al. (2023) · Nature

Protein Structure and DynamicsMachine Learning in Bioinformatics

Cited by 2,325

Design of protein-binding proteins from the target structure alone

Cao, L., Coventry, B., Goreshnik, I., Huang, B., Sheffler, W., Park, J. S., Jude, K. M., Marković, I., Kadam, R. U., Verschueren, K. H. G., et al. (2022) · Nature

Protein Structure and DynamicsChemical Synthesis and Analysis

Cited by 577

De novo design of a fluorescence-activating β-barrel

Dou, J., Vorobieva, A. A., Sheffler, W., Doyle, L. A., Park, H., Bick, M. J., Mao, B., Foight, G. W., Lee, M. Y., Gagnon, L. A., et al. (2018) · Nature

Protein Structure and DynamicsBiochemical and Structural Characterization

Cited by 351

Efficient flexible backbone protein-protein docking for challenging targets

Marze, N. A., Roy Burman, S. S., Sheffler, W., & Gray, J. J. (2018) · Bioinformatics

Protein Structure and DynamicsComputational Drug Discovery Methods

Cited by 173

Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site

Strauch, E.-M., Bernard, S. M., La, D., Bohn, A. J., Lee, P. S., Anderson, C. E., Nieusma, T., Holstein, C. A., Garcia, N. K., Hooper, K. A., et al. (2017) · Nature Biotechnology

Influenza Virus Research StudiesProtein Structure and Dynamics

Cited by 119

Bond-centric modular design of protein assemblies

Wang, S., Favor, A., Kibler, R. D., Lubner, J. M., Borst, A. J., Coudray, N., Redler, R. L., Chiang, H. T., Sheffler, W., Hsia, Y., et al. (2025) · Nature Materials

Supramolecular Self-Assembly in MaterialsBiochemical and Structural Characterization

Cited by 22

Bond-centric modular design of protein assemblies

Wang, S., Favor, A., Kibler, R. D., Lubner, J. M., Borst, A. J., Coudray, N., Redler, R., Chiang, H. T., Sheffler, W., Hsia, Y., et al. (2024) · Nature Materials

Supramolecular Self-Assembly in MaterialsBiochemical and Structural Characterization

Cited by 22