Ruff, Marc

Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage

Le Rouzic, E., Bonnard, D., Chasset, S., Bruneau, J.-M., Chevreuil, F., Le Strat, F., Nguyen, J., Beauvoir, R., Amadori, C., Brias, J., et al. (2013) · Retrovirology

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 127

Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors

Osz, J., Brélivet, Y., Peluso-Iltis, C., Cura, V., Eiler, S., Ruff, M., Bourguet, W., Rochel, N., & Moras, D. (2012) · Proceedings of the National Academy of Sciences

Estrogen and related hormone effectsNuclear Receptors and Signaling

Cited by 84

Intasome architecture and chromatin density modulate retroviral integration into nucleosome

Benleulmi, M. S., Matysiak, J., Henriquez, D. R., Vaillant, C., Lesbats, P., Calmels, C., Naughtin, M., Leon, O., Skalka, A. M., Ruff, M., et al. (2015) · Retrovirology

Virus-based gene therapy researchHIV Research and Treatment

Cited by 47

Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration

Bonnard, D., Le Rouzic, E., Eiler, S., Amadori, C., Orlov, I., Bruneau, J.-M., Brias, J., Barbion, J., Chevreuil, F., Spehner, D., et al. (2018) · Journal of Biological Chemistry

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 42

The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity

Amadori, C., van der Velden, Y. U., Bonnard, D., Orlov, I., van Bel, N., Le Rouzic, E., Miralles, L., Brias, J., Chevreuil, F., Spehner, D., et al. (2017) · Retrovirology

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 22