Rad, Roland

NASH limits anti-tumour surveillance in immunotherapy-treated HCC

Pfister, D., Núñez, N. G., Pinyol, R., Govaere, O., Pinter, M., Szydlowska, M., Gupta, R., Qiu, M., Deczkowska, A., Weiner, A., et al. (2021) · Nature

Cancer Immunotherapy and BiomarkersHepatocellular Carcinoma Treatment and Prognosis

Cited by 1,294

Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry

Bassani-Sternberg, M., Bräunlein, E., Klar, R., Engleitner, T., Sinitcyn, P., Audehm, S., Straub, M., Weber, J., Slotta-Huspenina, J., Specht, K., et al. (2016) · Nature Communications

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 693

Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice

Lawley, T. D., Clare, S., Walker, A. W., Stares, M. D., Connor, T. R., Raisen, C., Goulding, D., Rad, R., Schreiber, F., Brandt, C., et al. (2012) · PLoS Pathogens

Clostridium difficile and Clostridium perfringens researchGut microbiota and health

Cited by 540

Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis

McKerrell, T., Park, N., Moreno, T., Grove, C. S., Ponstingl, H., Stephens, J., Crawley, C., Craig, J., Scott, M. A., Hodkinson, C., et al. (2015) · Cell Reports

Acute Myeloid Leukemia ResearchCancer Genomics and Diagnostics

Cited by 534

Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH

Dudek, M., Pfister, D., Donakonda, S., Filpe, P., Schneider, A., Laschinger, M., Hartmann, D., Hüser, N., Meiser, P., Bayerl, F., et al. (2021) · Nature

Liver Disease Diagnosis and TreatmentLiver Diseases and Immunity

Cited by 518

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

Malehmir, M., Pfister, D., Gallage, S., Szydlowska, M., Inverso, D., Kotsiliti, E., Leone, V., Peiseler, M., Surewaard, B. G. J., Rath, D., et al. (2019) · Nature Medicine

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 398

Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer

Eser, S., Reiff, N., Messer, M., Seidler, B., Gottschalk, K., Dobler, M., Hieber, M., Arbeiter, A., Klein, S., Kong, B., et al. (2013) · Cancer Cell

Pancreatic and Hepatic Oncology ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 360

Intestinal B cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling

Kotsiliti, E., Leone, V., Schuehle, S., Govaere, O., Li, H., Wolf, M. J., Horvatic, H., Bierwirth, S., Hundertmark, J., Inverso, D., et al. (2023) · Journal of Hepatology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 108

A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection

Bosch, M., Kallin, N., Donakonda, S., Zhang, J. D., Wintersteller, H., Hegenbarth, S., Heim, K., Ramirez, C., Fürst, A., Lattouf, E. I., et al. (2024) · Nature

Hepatitis B Virus StudiesT-cell and B-cell Immunology

Cited by 97

Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf −/− mouse model

Chapeau, E. A., Gembarska, A., Durand, E. Y., Mandon, E., Estadieu, C., Romanet, V., Wiesmann, M., Tiedt, R., Lehar, J., de Weck, A., et al. (2017) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysChromatin Remodeling and Cancer

Cited by 64

A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer

Lier, S., Sellmer, A., Orben, F., Heinzlmeir, S., Krauß, L., Schneeweis, C., Hassan, Z., Schneider, C., Patricia Gloria Schäfer, A., Pongratz, H., et al. (2022) · Bioorganic Chemistry

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 37

c-Rel gain in B cells drives germinal center reactions and autoantibody production

Kober-Hasslacher, M., Oh-Strauß, H., Kumar, D., Soberon, V., Diehl, C., Lech, M., Engleitner, T., Katab, E., Fernández-Sáiz, V., Piontek, G., et al. (2020) · Journal of Clinical Investigation

NF-κB Signaling PathwaysT-cell and B-cell Immunology

Cited by 24

Functional Genomic Screening During Somatic Cell Reprogramming Identifies DKK3 as a Roadblock of Organ Regeneration

Arnold, F., Mahaddalkar, P. U., Kraus, J. M., Zhong, X., Bergmann, W., Srinivasan, D., Gout, J., Roger, E., Beutel, A. K., Zizer, E., et al. (2021) · Advanced Science

Liver physiology and pathologyPluripotent Stem Cells Research

Cited by 18

Auto-Aggressive CXCR6(+) CD8 T Cells Cause Liver Immune Pathology in NASH

Dudek, M., Knolle, P., Pfister, D., Heikenwälder, M., Donakonda, S., Laschinger, M., Hartmann, D., Hüser, N., Sebode, M., Filpe, P., et al. (2022) · Zeitschrift für Gastroenterologie

Liver Disease Diagnosis and TreatmentLiver Diseases and Immunity

Cited by 18