Brunsveld, Luc

Modulators of Protein–Protein Interactions

Milroy, L.-G., Grossmann, T. N., Hennig, S., Brunsveld, L., & Ottmann, C. (2014) · Chemical Reviews

14-3-3 protein interactionsChemical Synthesis and Analysis

Cited by 497

Stabilization and Inhibition of Protein–Protein Interactions: The 14-3-3 Case Study

Milroy, L.-G., Brunsveld, L., & Ottmann, C. (2013) · ACS Chemical Biology

14-3-3 protein interactionsChemical Synthesis and Analysis

Cited by 88

Synthesis and Crystal Structure of a Phosphorylated Estrogen Receptor Ligand Binding Domain

Möcklinghoff, S., Rose, R., Carraz, M., Visser, A., Ottmann, C., & Brunsveld, L. (2010) · ChemBioChem

Chemical Synthesis and AnalysisEstrogen and related hormone effects

Cited by 87

Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactions

Sijbesma, E., Visser, E., Plitzko, K., Thiel, P., Milroy, L.-G., Kaiser, M., Brunsveld, L., & Ottmann, C. (2020) · Nature Communications

14-3-3 protein interactionsComputational Drug Discovery Methods

Cited by 72

Proline primed helix length as a modulator of the nuclear receptor-coactivator interaction

Fuchs, S., Nguyen, H. D., Phan, T. T. P., Burton, M. F., Nieto, L., de Vries-van Leeuwen, I. J., Schmidt, A., Goodarzifard, M., Agten, S. M., Rose, R., et al. (2013) · Journal of the American Chemical Society

Estrogen and related hormone effectsProtein Structure and Dynamics

Cited by 43

Cooperativity between the orthosteric and allosteric ligand binding sites of RORγt

de Vries, R. M. J. M., Meijer, F. A., Doveston, R. G., Leijten-van de Gevel, I. A., & Brunsveld, L. (2021) · Proceedings of the National Academy of Sciences

Receptor Mechanisms and SignalingProtein Structure and Dynamics

Cited by 38