Wertz, Ingrid E.
Bristol-Myers Squibb (United States)
8 papers on CoChatORCID 0000-0002-7979-9374
Most cited papers
- Verified
Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)
Leverson, J. D., Zhang, H., Chen, J., Tahir, S. K., Phillips, D. C., Xue, J., Nimmer, P., Jin, S., Smith, M., Xiao, Y., et al. (2015) · Cell Death & Disease
Cell death mechanisms and regulationCancer-related Molecular Pathways
Cited by 440
- Verified
USP7 small-molecule inhibitors interfere with ubiquitin binding.
Kategaya, L., Di Lello, P., Rougé, L., Pastor, R., Clark, K. R., Drummond, J., Kleinheinz, T., Lin, E., Upton, J.-P., Prakash, S., et al. (2017) · Nature
Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors
Cited by 333
- Verified
Molecular glue CELMoD compounds are regulators of cereblon conformation
Watson, E. R., Novick, S., Matyskiela, M. E., Chamberlain, P. P., H. de la Peña, A., Zhu, J., Tran, E., Griffin, P. R., Wertz, I. E., & Lander, G. C. (2022) · Science
Protein Degradation and InhibitorsUbiquitin and proteasome pathways
Cited by 208
- Verified
Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα)
Dragovich, P. S., Adhikari, P., Blake, R. A., Blaquiere, N., Chen, J., Cheng, Y.-X., den Besten, W., Han, J., Hartman, S. J., He, J., et al. (2020) · Bioorganic & Medicinal Chemistry Letters
Protein Degradation and InhibitorsMonoclonal and Polyclonal Antibodies Research
Cited by 120
- Verified
Molecular understanding of USP7 substrate recognition and c-terminal activation.
Rougé, L., Bainbridge, T. W., Kwok, M., Tong, R., Di Lello, P., Wertz, I. E., Maurer, T., Ernst, J. A., & Murray, J. (2016) · Structure
Ubiquitin and proteasome pathwaysEnzyme Structure and Function
Cited by 108
- Verified
Discovery of small-molecule inhibitors of ubiquitin specific protease 7 (USP7) using integrated NMR and in silico techniques
Di Lello, P., Pastor, R., Murray, J. M., Blake, R. A., Cohen, F., Crawford, T. D., Drobnick, J., Drummond, J., Kategaya, L., Kleinheinz, T., et al. (2017) · Journal of Medicinal Chemistry
Ubiquitin and proteasome pathwaysComputational Drug Discovery Methods
Cited by 90
- Verified
Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity
Zammit, N. W., Siggs, O. M., Gray, P. E., Horikawa, K., Langley, D. B., Walters, S. N., Daley, S. R., Loetsch, C., Warren, J., Yap, J. Y., et al. (2019) · Nature Immunology
NF-κB Signaling PathwaysImmune Response and Inflammation
Cited by 80
- Verified
PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network
Reichermeier, K. M., Straube, R., Reitsma, J. M., Sweredoski, M. J., Rose, C. M., Moradian, A., den Besten, W., Hinkle, T., Verschueren, E., Petzold, G., et al. (2020) · Molecular Cell
Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors
Cited by 78
Go further with a free account
Verify every reference, keep papers in a library, and ask questions across them.
Sign up - it is free