Hulea, Laura

Targeting the translation machinery in cancer

Bhat, M., Robichaud, N., Hulea, L., Sonenberg, N., Pelletier, J., & Topisirovic, I. (2015) · Nature Reviews Drug Discovery

RNA and protein synthesis mechanismsPI3K/AKT/mTOR signaling in cancer

Cited by 799

mTOR coordinates protein synthesis, mitochondrial activity and proliferation

Morita, M., Gravel, S.-P., Hulea, L., Larsson, O., Pollak, M., St-Pierre, J., & Topisirovic, I. (2015) · Cell Cycle

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 552

The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway

Carbonneau, M., M. Gagné, L., Lalonde, M.-E., Germain, M.-A., Motorina, A., Guiot, M.-C., Secco, B., Vincent, E. E., Tumber, A., Hulea, L., et al. (2016) · Nature Communications

Cancer, Hypoxia, and MetabolismPI3K/AKT/mTOR signaling in cancer

Cited by 180

Serine deprivation enhances antineoplastic activity of biguanides

Gravel, S.-P., Hulea, L., Toban, N., Birman, E., Blouin, M.-J., Zakikhani, M., Zhao, Y., Topisirovic, I., St-Pierre, J., & Pollak, M. (2014) · Cancer Research

Metabolism, Diabetes, and CancerCancer, Hypoxia, and Metabolism

Cited by 138

A hydride transfer complex reprograms NAD metabolism and bypasses senescence

Igelmann, S., Lessard, F., Uchenunu, O., Bouchard, J., Fernandez-Ruiz, A., Rowell, M.-C., Lopes-Paciencia, S., Papadopoli, D., Fouillen, A., Ponce, K. J., et al. (2021) · Molecular Cell

Telomeres, Telomerase, and SenescenceSirtuins and Resveratrol in Medicine

Cited by 60

O-GlcNAcylation of FOXK1 orchestrates the E2F pathway and promotes oncogenesis

Masclef, L., Ahmed, O., Iannantuono, N., Gagnon, J., Gushul-Leclaire, M., Boulay, K., Estavoyer, B., Echbicheb, M., Poy, M., Ali Boubacar, K., et al. (2024) · Nature Communications

Cancer-related Molecular PathwaysGlycosylation and Glycoproteins Research

Cited by 6