Pyke, Charles

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss

Secher, A., Jelsing, J., Baquero, A. F., Hecksher-Sørensen, J., Cowley, M. A., Dalbøge, L. S., Hansen, G., Grove, K. L., Pyke, C., Raun, K., et al. (2014) · Journal of Clinical Investigation

Regulation of Appetite and ObesityDiabetes Treatment and Management

Cited by 961

GLP-1 Receptor Localization in Monkey and Human Tissue: Novel Distribution Revealed With Extensively Validated Monoclonal Antibody

Pyke, C., Heller, R. S., Kirk, R. K., Ørskov, C., Reedtz-Runge, S., Kaastrup, P., Hvelplund, A., Bardram, L., Calatayud, D., & Knudsen, L. B. (2014) · Endocrinology

Diabetes Treatment and ManagementPancreatic function and diabetes

Cited by 876

Semaglutide lowers body weight in rodents via distributed neural pathways.

Gabery, S., Salinas, C. G., Paulsen, S. J., Ahnfelt-Rønne, J., Alanentalo, T., Baquero, A. F., Buckley, S. T., Farkas, E., Fekete, C., Frederiksen, K. S., et al. (2020) · JCI Insight

Regulation of Appetite and ObesityDiabetes Treatment and Management

Cited by 717

Transcellular Stomach Absorption of a Derivatized Glucagon-Like Peptide-1 Receptor Agonist

Buckley, S. T., Bækdal, T. A., Vegge, A., Maarbjerg, S. J., Pyke, C., Ahnfelt-Rønne, J., Madsen, K. G., Schéele, S. G., Alanentalo, T., Kirk, R. K., et al. (2018) · Science Translational Medicine

Drug Solubulity and Delivery SystemsAdvanced Drug Delivery Systems

Cited by 553

A genetic map of the mouse dorsal vagal complex and its role in obesity

Ludwig, M. Q., Cheng, W., Gordian, D., Lee, J., Paulsen, S. J., Hansen, S. N., Egerod, K. L., Barkholt, P., Rhodes, C. J., Secher, A., et al. (2021) · Nature Metabolism

Regulation of Appetite and ObesityNeuropeptides and Animal Physiology

Cited by 186

The Glucagon-Like Peptide-1 Receptor—or Not?

Pyke, C., & Knudsen, L. B. (2013) · Endocrinology

Diabetes Treatment and ManagementReceptor Mechanisms and Signaling

Cited by 154

Characterization of the Glucagonlike Peptide-1 Receptor in Male Mouse Brain Using a Novel Antibody and In Situ Hybridization

Jensen, C. B., Pyke, C., Rasch, M. G., Dahl, A. B., Knudsen, L. B., & Secher, A. (2018) · Endocrinology

Regulation of Appetite and ObesityDiabetes Treatment and Management

Cited by 145

GLP-1 Induces Barrier Protective Expression in Brunnerʼs Glands and Regulates Colonic Inflammation

Bang-Berthelsen, C. H., Holm, T. L., Pyke, C., Simonsen, L., Søkilde, R., Pociot, F., Heller, R. S., Folkersen, L., Kvist, P. H., Jackerott, M., et al. (2016) · Inflammatory Bowel Diseases

Inflammatory Bowel DiseaseIL-33, ST2, and ILC Pathways

Cited by 111

A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing

Dowsett, G. K. C., Lam, B. Y. H., Tadross, J. A., Cimino, I., Rimmington, D., Coll, A. P., Polex-Wolf, J., Knudsen, L. B., Pyke, C., & Yeo, G. S. H. (2021) · Molecular Metabolism

Regulation of Appetite and ObesitySingle-cell and spatial transcriptomics

Cited by 98

Glucagon‐like peptide‐1 receptor expression in the human eye

Hebsgaard, J. B., Pyke, C., Yildirim, E., Knudsen, L. B., Heegaard, S., & Kvist, P. H. (2018) · Diabetes, Obesity and Metabolism

Retinal Diseases and TreatmentsDiabetes Treatment and Management

Cited by 88

Activation of the renal GLP‐1R leads to expression of Ren1 in the renal vascular tree

Bjørnholm, K. D., Ougaard, M. E., Skovsted, G. F., Knudsen, L. B., & Pyke, C. (2021) · Endocrinology, Diabetes & Metabolism

Renin-Angiotensin System StudiesDiabetes Treatment and Management

Cited by 16

Decreased expression of the GLP-1 receptor after segmental artery injury in mice

Bjørnholm, K. D., Povlsen, G. K., Ougaard, M. E., Pyke, C., Rakipovski, G., Tveden-Nyborg, P., Lykkesfeldt, J., & Skovsted, G. F. (2021) · Journal of Endocrinology

Chronic Kidney Disease and DiabetesDiabetes Treatment and Management

Cited by 10

Ultrastructural Visualization of Insulin Degludec Multi-hexamers in the Subcutaneous Depot In Vivo Supports a Unique Mechanism of Protraction

Seested, T., Havelund, S., Jonassen, I. B., Hoeg-Jensen, T., Pyke, C., Kapor, J., & Nishimura, E. (2012) · Canadian Journal of Diabetes

Diabetes Management and ResearchDiabetes Treatment and Management

Cited by 5