Gulen, Muhammet F.

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

Glück, S., Guey, B., Gulen, M. F., Wolter, K., Kang, T.-W., Schmacke, N. A., Bridgeman, A., Rehwinkel, J., Zender, L., & Ablasser, A. (2017) · Nature Cell Biology

Telomeres, Telomerase, and Senescenceinterferon and immune responses

Cited by 1,196

Targeting STING with covalent small-molecule inhibitors

Haag, S. M., Gulen, M. F., Reymond, L., Gibelin, A., Abrami, L., Decout, A., Heymann, M., van der Goot, F. G., Turcatti, G., Behrendt, R., et al. (2018) · Nature

interferon and immune responsesImmune Response and Inflammation

Cited by 1,178

cGAS–STING drives ageing-related inflammation and neurodegeneration

Gulen, M. F., Samson, N., Keller, A., Schwabenland, M., Liu, C., Glück, S., Thacker, V. V., Favre, L., Mangeat, B., Kroese, L. J., et al. (2023) · Nature

Neuroinflammation and Neurodegeneration Mechanismsinterferon and immune responses

Cited by 1,104

Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability

Lee, J. S., Tato, C. M., Joyce-Shaikh, B., Gulen, M. F., Cayatte, C., Chen, Y., Blumenschein, W. M., Judo, M., Ayanoglu, G., McClanahan, T. K., et al. (2015) · Immunity

Psoriasis: Treatment and PathogenesisInflammatory Bowel Disease

Cited by 760

The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease

Qian, Y., Liu, C., Hartupee, J., Altuntas, C. Z., Gulen, M. F., Jane-wit, D., Xiao, J., Lu, Y., Giltiay, N., Liu, J., et al. (2007) · Nature Immunology

Psoriasis: Treatment and PathogenesisNF-κB Signaling Pathways

Cited by 614

The cGAS–STING pathway drives type I IFN immunopathology in COVID-19

Domizio, J. D., Gulen, M. F., Saidoune, F., Thacker, V. V., Yatim, A., Sharma, K., Nass, T., Guenova, E., Schaller, M., Conrad, C., et al. (2022) · Nature

interferon and immune responsesSARS-CoV-2 and COVID-19 Research

Cited by 538

Signalling strength determines proapoptotic functions of STING

Gulen, M. F., Koch, U., Haag, S. M., Schuler, F., Apetoh, L., Villunger, A., Radtke, F., & Ablasser, A. (2017) · Nature Communications

interferon and immune responsesImmune Response and Inflammation

Cited by 505

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1

Wassermann, R., Gulen, M. F., Sala, C., Perin, S. G., Lou, Y., Rybniker, J., Schmid-Burgk, J. L., Schmidt, T., Hornung, V., Cole, S. T., et al. (2015) · Cell Host & Microbe

Tuberculosis Research and Epidemiologyinterferon and immune responses

Cited by 401

Astrocyte-restricted ablation of interleukin-17-induced ACT1-mediated signaling ameliorates autoimmune encephalomyelitis

Kang, Z., Altuntas, C. Z., Gulen, M. F., Liu, C., Giltiay, N., Qin, H., Liu, L., Qian, W., Ransohoff, R. M., Bergmann, C., et al. (2010) · Immunity

Multiple Sclerosis Research StudiesPsoriasis: Treatment and Pathogenesis

Cited by 297

The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation

Bulek, K., Liu, C., Swaidani, S., Wang, L., Page, R. C., Gulen, M. F., Herjan, T., Abbadi, A., Qian, W., Sun, D., et al. (2011) · Nature Immunology

NF-κB Signaling PathwaysCytokine Signaling Pathways and Interactions

Cited by 192

IL-17-Induced Act1-Mediated Signaling Is Critical for Cuprizone-Induced Demyelination

Kang, Z., Liu, L., Spangler, R., Spear, C., Wang, C., Gulen, M. F., Veenstra, M., Ouyang, W., Ransohoff, R. M., & Li, X. (2012) · Journal of Neuroscience

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 78