Xu, Wenqing

β-Catenin destruction complex: insights and questions from a structural perspective

Kimelman, D., & Xu, W. (2006) · Oncogene

Wnt/β-catenin signaling in development and cancerSignaling Pathways in Disease

Cited by 628

Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme

Cho, U. S., & Xu, W. (2007) · Nature

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 459

MeCP2 Suppresses Nuclear MicroRNA Processing and Dendritic Growth by Regulating the DGCR8/Drosha Complex

Cheng, T.-L., Wang, Z., Liao, Q., Zhu, Y., Zhou, W.-H., Xu, W., & Qiu, Z. (2014) · Developmental Cell

Genetics and Neurodevelopmental DisordersMicroRNA in disease regulation

Cited by 270

Crystal structure of a β-catenin/Axin complex suggests a mechanism for the β-catenin destruction complex

Xing, Y., Clements, W. K., Kimelman, D., & Xu, W. (2003) · Genes & Development

Wnt/β-catenin signaling in development and cancerSignaling Pathways in Disease

Cited by 237

Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth

Sangodkar, J., Perl, A., Tohme, R., Kiselar, J., Kastrinsky, D. B., Zaware, N., Izadmehr, S., Mazhar, S., Wiredja, D. D., O’Connor, C. M., et al. (2017) · Journal of Clinical Investigation

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 196

Selective PP2A enhancement through biased heterotrimer stabilization

Leonard, D., Huang, W., Izadmehr, S., O’Connor, C. M., Wiredja, D. D., Wang, Z., Zaware, N., Chen, Y., Schlatzer, D. M., Kiselar, J., et al. (2020) · Cell

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 176

Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol

Zhang, L., Zhao, Y., Gao, Y., Wu, L., Gao, R., Zhang, Q., Wang, Y., Wu, C., Wu, F., Gurcha, S. S., et al. (2020) · Science

Tuberculosis Research and EpidemiologyEnzyme Structure and Function

Cited by 173

Crystal structure of a membrane-bound O-acyltransferase

Ma, D., Wang, Z., Merrikh, C. N., Lang, K. S., Lu, P., Li, X., Merrikh, H., Rao, Z., & Xu, W. (2018) · Nature

Bacterial Genetics and BiotechnologyEnzyme Structure and Function

Cited by 105

Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56

Wang, J., Okkeri, J., Pavic, K., Wang, Z., Kauko, O., Halonen, T., Sarek, G., Ojala, P. M., Rao, Z., Xu, W., et al. (2017) · The EMBO Reports

Cancer Mechanisms and TherapySignaling Pathways in Disease

Cited by 95

The SIAH E3 ubiquitin ligases promote Wnt/β-catenin signaling through mediating Wnt-induced Axin degradation

Ji, L., Jiang, B., Jiang, X., Charlat, O., Chen, A., Mickanin, C., Bauer, A., Xu, W., Yan, X., & Cong, F. (2017) · Genes & Development

Wnt/β-catenin signaling in development and cancerUbiquitin and proteasome pathways

Cited by 89

Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization

Wang, J., Wang, Z., Yu, T., Yang, H., Virshup, D. M., Kops, G. J. P. L., Lee, S. H., Zhou, W., Li, X., Xu, W., et al. (2016) · Protein & Cell

Microtubule and mitosis dynamicsGenomics and Chromatin Dynamics

Cited by 80

Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors

O’Connor, C. M., Leonard, D., Wiredja, D., Avelar, R. A., Wang, Z., Schlatzer, D., Bryson, B., Tokala, E., Taylor, S. E., Upadhyay, A., et al. (2020) · Oncogene

Protein Tyrosine PhosphatasesMelanoma and MAPK Pathways

Cited by 48

Structural Basis of the Interaction between Tuberous Sclerosis Complex 1 (TSC1) and Tre2-Bub2-Cdc16 Domain Family Member 7 (TBC1D7)

Qin, J., Wang, Z., Hoogeveen-Westerveld, M., Shen, G., Gong, W., Nellist, M., & Xu, W. (2016) · Journal of Biological Chemistry

Tuberous Sclerosis Complex ResearchPI3K/AKT/mTOR signaling in cancer

Cited by 37

Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A

Pavic, K., Gupta, N., Omella, J. D., Derua, R., Aakula, A., Huhtaniemi, R., Määttä, J. A., Höfflin, N., Okkeri, J., Wang, Z., et al. (2023) · Nature Communications

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 36

Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations

Sun, W., Zhu, Y. J., Wang, Z., Zhong, Q., Gao, F., Lou, J., Gong, W., & Xu, W. (2013) · Nature Communications

Tuberous Sclerosis Complex ResearchPI3K/AKT/mTOR signaling in cancer

Cited by 27