Counter, Christopher M.

Creation of human tumour cells with defined genetic elements

Hahn, W. C., Counter, C. M., Lundberg, A. S., Beijersbergen, R. L., Brooks, M. W., & Weinberg, R. A. (1999) · Nature

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 2,345

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

Counter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B., & Bacchetti, S. (1992) · The EMBO Journal

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 2,096

hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization

Meyerson, M., Counter, C. M., Eaton, E. N., Ellisen, L. W., Steiner, P., Caddle, S. D., Ziaugra, L., Beijersbergen, R. L., Davidoff, M. J., Liu, Q., et al. (1997) · Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,784

A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells

Yeh, E., Cunningham, M., Arnold, H., Chasse, D., Monteith, T., Ivaldi, G., Hahn, W. C., Stukenberg, P. T., Shenolikar, S., Uchida, T., et al. (2004) · Nature Cell Biology

Signaling Pathways in DiseaseProtein Kinase Regulation and GTPase Signaling

Cited by 791

Telomerase activity in human ovarian carcinoma.

Counter, C. M., Hirte, H. W., Bacchetti, S., & Harley, C. B. (1994) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceOvarian cancer diagnosis and treatment

Cited by 677

Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

Counter, C. M., Hahn, W. C., Wei, W., Caddle, S. D., Beijersbergen, R. L., Lansdorp, P. M., Sedivy, J. M., & Weinberg, R. A. (1998) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 649

Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis

Ancrile, B., Lim, K.-H., & Counter, C. M. (2007) · Genes & Development

Cytokine Signaling Pathways and InteractionsProtein Kinase Regulation and GTPase Signaling

Cited by 422

Telomerase, Cell Immortality, and Cancer

Harley, C. B., Kim, N. W., Prowse, K. R., Weinrich, S. L., Hirsch, K. S., West, M. D., Bacchetti, S., Hirte, H. W., Counter, C. M., Greider, C. W., et al. (1994) · Cold Spring Harbor Symposia on Quantitative Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 396

A model for RAS mutation patterns in cancers: finding the sweet spot

Li, S., Balmain, A., & Counter, C. M. (2018) · Nature Reviews Cancer

Protein Kinase Regulation and GTPase SignalingCancer Genomics and Diagnostics

Cited by 384

RALA and RALBP1 regulate mitochondrial fission at mitosis

Kashatus, D. F., Lim, K.-H., Brady, D. C., Pershing, N. L. K., Cox, A. D., & Counter, C. M. (2011) · Nature Cell Biology

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 380

Activation of RalA is critical for Ras-induced tumorigenesis of human cells

Lim, K.-H., Baines, A. T., Fiordalisi, J. J., Shipitsin, M., Feig, L. A., Cox, A. D., Der, C. J., & Counter, C. M. (2005) · Cancer Cell

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 355

Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes

Counter, C. M., Botelho, F. M., Wang, P., Harley, C. B., & Bacchetti, S. (1994) · Journal of Virology

Telomeres, Telomerase, and SenescenceViral-associated cancers and disorders

Cited by 355

The Cytoplasmic Deacetylase HDAC6 Is Required for Efficient Oncogenic Tumorigenesis

Lee, Y.-S., Lim, K.-H., Guo, X., Kawaguchi, Y., Gao, Y., Barrientos, T., Ordentlich, P., Wang, X.-F., Counter, C. M., & Yao, T.-P. (2008) · Cancer Research

Histone Deacetylase Inhibitors ResearchCancer, Lipids, and Metabolism

Cited by 260

Divergent Roles for RalA and RalB in Malignant Growth of Human Pancreatic Carcinoma Cells

Lim, K.-H., O'Hayer, K., Adam, S. J., Kendall, S. D., Campbell, P. M., Der, C. J., & Counter, C. M. (2006) · Current Biology

Protein Kinase Regulation and GTPase SignalingPancreatic and Hepatic Oncology Research

Cited by 250

Aurora-A Phosphorylates, Activates, and Relocalizes the Small GTPase RalA

Lim, K.-H., Brady, D. C., Kashatus, D. F., Ancrile, B. B., Der, C. J., Cox, A. D., & Counter, C. M. (2010) · Molecular and Cellular Biology

Protein Kinase Regulation and GTPase SignalingMicrotubule and mitosis dynamics

Cited by 126

A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution

Anderson, G. R., Winter, P. S., Lin, K. H., Nussbaum, D. P., Cakir, M., Stein, E. M., Soderquist, R. S., Crawford, L., Leeds, J. C., Newcomb, R., et al. (2017) · Cell Reports

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 80

Rare codons capacitate Kras-driven de novo tumorigenesis

Pershing, N. L. K., Lampson, B. L., Belsky, J. A., Kaltenbrun, E., MacAlpine, D. M., & Counter, C. M. (2015) · Journal of Clinical Investigation

RNA and protein synthesis mechanismsProtein Kinase Regulation and GTPase Signaling

Cited by 77

Ral activation promotes melanomagenesis

Zipfel, P. A., Brady, D. C., Kashatus, D. F., Ancrile, B. D., Tyler, D. S., & Counter, C. M. (2010) · Oncogene

Melanoma and MAPK PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 47

Breaking up is hard to do: RalA, mitochondrial fission and cancer

Kashatus, D. F., & Counter, C. M. (2011) · Small GTPases

Protein Kinase Regulation and GTPase SignalingMitochondrial Function and Pathology

Cited by 12