Wittler, Lars

Disruptions of Topological Chromatin Domains Cause Pathogenic Rewiring of Gene-Enhancer Interactions

Lupiáñez, D. G., Kraft, K., Heinrich, V., Krawitz, P., Brancati, F., Klopocki, E., Horn, D., Kayserili, H., Opitz, J. M., Laxova, R., et al. (2015) · Cell

Genomics and Chromatin DynamicsGenomic variations and chromosomal abnormalities

Cited by 2,132

Formation of new chromatin domains determines pathogenicity of genomic duplications

Franke, M., Ibrahim, D. M., Andrey, G., Schwarzer, W., Heinrich, V., Schöpflin, R., Kraft, K., Kempfer, R., Jerković, I., Chan, W.-L., et al. (2016) · Nature

Genomics and Chromatin DynamicsGenomic variations and chromosomal abnormalities

Cited by 673

Preformed chromatin topology assists transcriptional robustness of Shh during limb development

Paliou, C., Guckelberger, P., Schöpflin, R., Heinrich, V., Esposito, A., Chiariello, A. M., Bianco, S., Annunziatella, C., Helmuth, J., Haas, S., et al. (2019) · Proceedings of the National Academy of Sciences

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 163

In vivo dissection of a clustered-CTCF domain boundary reveals developmental principles of regulatory insulation

Anania, C., Acemel, R. D., Jedamzick, J., Bolondi, A., Cova, G., Brieske, N., Kühn, R., Wittler, L., Real, F. M., & Lupiáñez, D. G. (2021) · Nature Genetics

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 77

The mole genome reveals regulatory rearrangements associated with adaptive intersexuality

M. Real, F., Haas, S. A., Franchini, P., Xiong, P., Simakov, O., Kuhl, H., Schöpflin, R., Heller, D., Moeinzadeh, M.-H., Heinrich, V., et al. (2020) · Science

Genetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesSexual Differentiation and Disorders

Cited by 66

Patterning and gastrulation defects caused by the tw18 lethal are due to loss of Ppp2r1a

Lange, L., Marks, M., Liu, J., Wittler, L., Bauer, H., Piehl, S., Bläß, G., Timmermann, B., & Herrmann, B. G. (2017) · Biology Open

Developmental Biology and Gene RegulationWnt/β-catenin signaling in development and cancer

Cited by 19