Shaw, Pamela J.

Value of systematic genetic screening of patients with amyotrophic lateral sclerosis

Shepheard, S. R., Parker, M. D., Cooper-Knock, J., Verber, N. S., Tuddenham, L., Heath, P., Beauchamp, N., Place, E., Sollars, E. S. A., Turner, M. R., et al. (2021) · Journal of Neurology, Neurosurgery & Psychiatry

Amyotrophic Lateral Sclerosis ResearchHereditary Neurological Disorders

Cited by 116

Development and characterisation of a glutamate-sensitive motor neurone cell line

Eggett, C. J., Crosier, S., Manning, P., Cookson, M. R., Menzies, F. M., McNeil, C. J., & Shaw, P. J. (2000) · Journal of Neurochemistry

Neuroscience and Neuropharmacology ResearchAmino Acid Enzymes and Metabolism

Cited by 111

Physical activity as an exogenous risk factor in motor neuron disease (MND): A review of the evidence

Harwood, C. A., McDermott, C. J., & Shaw, P. J. (2009) · Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders Research

Cited by 104

C9orf72 intermediate expansions of 24–30 repeats are associated with ALS

Initiative, A. D. N., Iacoangeli, A., Al Khleifat, A., Jones, A. R., Sproviero, W., Shatunov, A., Opie-Martin, S., Morrison, K. E., Shaw, P. J., Shaw, C. E., et al. (2019) · Acta Neuropathologica Communications

Amyotrophic Lateral Sclerosis ResearchGenetic Neurodegenerative Diseases

Cited by 102

Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders

study, T. A. I. B. A. L., Nabais, M. F., Initiative, T. A. D. N., Laws, S. M., Lin, T., Vallerga, C. L., Armstrong, N. J., Blair, I. P., Kwok, J. B., Mather, K. A., et al. (2021) · Genome Biology

Epigenetics and DNA MethylationDementia and Cognitive Impairment Research

Cited by 99

A data-driven approach links microglia to pathology and prognosis in amyotrophic lateral sclerosis

Cooper-Knock, J., Green, C., Altschuler, G., Wei, W., Bury, J. J., Heath, P. R., Wyles, M., Gelsthorpe, C., Highley, J. R., Lorente-Pons, A., et al. (2017) · Acta Neuropathologica Communications

Amyotrophic Lateral Sclerosis ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 80

Alterations of the blood-brain barrier in cerebral white matter lesions in the ageing brain

Simpson, J. E., Wharton, S. B., Cooper, J., Gelsthorpe, C., Baxter, L., Forster, G., Shaw, P. J., Savva, G., Matthews, F. E., Brayne, C., et al. (2010) · Neuroscience Letters

Barrier Structure and Function StudiesCerebrovascular and genetic disorders

Cited by 77

Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction

Wood, G. K., Sargent, B. F., Ahmad, Z.-U.-A., Tharmaratnam, K., Dunai, C., Egbe, F. N., Martin, N. H., Facer, B., Pendered, S. L., Rogers, H. C., et al. (2025) · Nature Medicine

Long-Term Effects of COVID-19Infectious Encephalopathies and Encephalitis

Cited by 67

The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain

Fluteau, A., Ince, P. G., Minett, T., Matthews, F. E., Brayne, C., Garwood, C. J., Ratcliffe, L. E., Morgan, S., Heath, P. R., Shaw, P. J., et al. (2015) · Neuroscience Letters

FOXO transcription factor regulationAlzheimer's disease research and treatments

Cited by 66

Concurrence of multiple sclerosis and amyotrophic lateral sclerosis in patients with hexanucleotide repeat expansions of C9ORF72

Ismail, A., Cooper-Knock, J., Highley, J. R., Milano, A., Kirby, J., Goodall, E., Lowe, J., Scott, I., Constantinescu, C. S., Walters, S. J., et al. (2013) · Journal of Neurology, Neurosurgery & Psychiatry

Amyotrophic Lateral Sclerosis ResearchMultiple Sclerosis Research Studies

Cited by 65

Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease.

Gatto, N., Dos Santos Souza, C., Shaw, A. C., Bell, S. M., Myszczynska, M. A., Powers, S., Meyer, K., Castelli, L. M., Karyka, E., Mortiboys, H., et al. (2021) · Aging Cell

Pluripotent Stem Cells ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 58

Oligodendrocyte pathology exceeds axonal pathology in white matter in human amyotrophic lateral sclerosis

Lorente Pons, A., Higginbottom, A., Cooper‐Knock, J., Alrafiah, A., Alofi, E., Kirby, J., Shaw, P. J., Wood, J. D., & Highley, J. R. (2020) · The Journal of Pathology

Amyotrophic Lateral Sclerosis ResearchHereditary Neurological Disorders

Cited by 57

A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort

Simpson, J. E., Ince, P. G., Matthews, F. E., Shaw, P. J., Heath, P. R., Brayne, C., Garwood, C., Higginbottom, A., Wharton, S. B., & MRC Cognitive Function and Ageing Neuropathology Study Group (2015) · Neuropathology and Applied Neurobiology

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 56

A Reduced Astrocyte Response to β-Amyloid Plaques in the Ageing Brain Associates with Cognitive Impairment

Mathur, R., Ince, P. G., Minett, T., Garwood, C. J., Shaw, P. J., Matthews, F. E., Brayne, C., Simpson, J. E., Wharton, S. B., & on behalf of the MRC Cognitive Function and Ageing Neuropathology Study Group (2015) · PLOS ONE

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 52

Calcium dysregulation in relation to Alzheimer‐type pathology in the ageing brain

Garwood, C., Faizullabhoy, A., Wharton, S. B., Ince, P. G., Heath, P. R., Shaw, P. J., Baxter, L., Gelsthorpe, C., Forster, G., Matthews, F. E., et al. (2013) · Neuropathology and Applied Neurobiology

Alzheimer's disease research and treatmentsCalpain Protease Function and Regulation

Cited by 47

The impact of fatigue and psychosocial variables on quality of life for patients with motor neuron disease

Gibbons, C., Thornton, E., Ealing, J., Shaw, P., Talbot, K., Tennant, A., & Young, C. (2013) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Amyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders Research

Cited by 41

Senescent-like Blood Lymphocytes and Disease Progression in Amyotrophic Lateral Sclerosis

Yildiz, O., Schroth, J., Tree, T., Turner, M. R., Shaw, P. J., Henson, S. M., & Malaspina, A. (2023) · Neurology Neuroimmunology & Neuroinflammation

Amyotrophic Lateral Sclerosis ResearchTelomeres, Telomerase, and Senescence

Cited by 39

Acceptance and Commitment Therapy plus usual care for improving quality of life in people with motor neuron disease (COMMEND): a multicentre, parallel, randomised controlled trial in the UK

Gould, R. L., McDermott, C. J., Thompson, B. J., Rawlinson, C. V., Bursnall, M., Bradburn, M., Kumar, P., Turton, E. J., White, D. A., Serfaty, M. A., et al. (2024) · The Lancet

Mindfulness and Compassion InterventionsAmyotrophic Lateral Sclerosis Research

Cited by 38

Whole-genome sequencing reveals that variants in the Interleukin 18 Receptor Accessory Protein 3′UTR protect against ALS

Eitan, C., Siany, A., Barkan, E., Olender, T., van Eijk, K. R., Moisse, M., Farhan, S. M. K., Danino, Y. M., Yanowski, E., Marmor-Kollet, H., et al. (2022) · Nature Neuroscience

Amyotrophic Lateral Sclerosis ResearchMultiple Sclerosis Research Studies

Cited by 38

Health utility decreases with increasing clinical stage in amyotrophic lateral sclerosis

Jones, A. R., Jivraj, N., Balendra, R., Murphy, C., Kelly, J., Thornhill, M., Young, C., Shaw, P. J., Leigh, P. N., Turner, M. R., et al. (2014) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Health Systems, Economic Evaluations, Quality of LifeAmyotrophic Lateral Sclerosis Research

Cited by 35

UK case control study of smoking and risk of amyotrophic lateral sclerosis

Opie-Martin, S., Jones, A., Iacoangeli, A., Al-Khleifat, A., Oumar, M., Shaw, P. J., Shaw, C. E., Morrison, K. E., Wootton, R. E., Davey-Smith, G., et al. (2020) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Amyotrophic Lateral Sclerosis ResearchSmoking Behavior and Cessation

Cited by 19

A randomised controlled trial of acceptance and commitment therapy plus usual care compared to usual care alone for improving psychological health in people with motor neuron disease (COMMEND): study protocol.

Gould, R. L., Thompson, B. J., Rawlinson, C., Kumar, P., White, D., Serfaty, M. A., Graham, C. D., McCracken, L. M., Bursnall, M., Bradburn, M., et al. (2022) · BMC Neurology

Mindfulness and Compassion InterventionsAmyotrophic Lateral Sclerosis Research

Cited by 16

Acceptance and Commitment Therapy for people living with motor neuron disease: an uncontrolled feasibility study

Gould, R. L., Rawlinson, C., Thompson, B., Weeks, K., Gossage-Worrall, R., Cantrill, H., Serfaty, M. A., Graham, C. D., McCracken, L. M., White, D., et al. (2023) · Pilot and Feasibility Studies

Mindfulness and Compassion InterventionsAmyotrophic Lateral Sclerosis Research

Cited by 10

Clinical aspects of motor neurone disease

Moore, C., McDermott, C. J., & Shaw, P. J. (2008) · Medicine

Amyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders Research

Cited by 5