Mitchell, James R.

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R.-M., Vijg, J., Van Steeg, H., Dollé, M. E. T., et al. (2014) · Developmental Cell

Wound Healing and TreatmentsTelomeres, Telomerase, and Senescence

Cited by 2,045

A telomerase component is defective in the human disease dyskeratosis congenita

Mitchell, J. R., Wood, E., & Collins, K. (1999) · Nature

Telomeres, Telomerase, and SenescenceNuclear Structure and Function

Cited by 1,168

Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

Fang, E. F., Scheibye-Knudsen, M., Brace, L. E., Kassahun, H., SenGupta, T., Nilsen, H., Mitchell, J. R., Croteau, D. L., & Bohr, V. A. (2014) · Cell

Autophagy in Disease and TherapyMitochondrial Function and Pathology

Cited by 711

Interventions to slow aging in humans: are we ready?

Longo, V. D., Antebi, A., Bartke, A., Barzilai, N., Brown‐Borg, H. M., Caruso, C., Curiel, T. J., Cabo, R., Franceschi, C., Gems, D., et al. (2015) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Cited by 592

Endogenous hydrogen sulfide production is essential for dietary restriction benefits

Hine, C., Harputlugil, E., Zhang, Y., Ruckenstuhl, C., Lee, B. C., Brace, L., Longchamp, A., Treviño-Villarreal, J. H., Mejia, P., Ozaki, C. K., et al. (2015) · Cell

Sulfur Compounds in BiologyGenetics, Aging, and Longevity in Model Organisms

Cited by 558

A Box H/ACA Small Nucleolar RNA-Like Domain at the Human Telomerase RNA 3′ End

Mitchell, J. R., Cheng, J., & Collins, K. (1999) · Molecular and Cellular Biology

Telomeres, Telomerase, and SenescenceNuclear Structure and Function

Cited by 510

Impairment of an endothelial NAD(+)-H2S signaling network is a reversible cause of vascular aging

Das, A., Huang, G. X., Bonkowski, M. S., Longchamp, A., Li, C., Schultz, M. B., Kim, L.-J., Osborne, B., Joshi, S., Lu, Y., et al. (2018) · Cell

Nitric Oxide and Endothelin EffectsSirtuins and Resveratrol in Medicine

Cited by 496

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice

Mitchell, S. J., Madrigal-Matute, J., Scheibye-Knudsen, M., Fang, E., Aon, M., González-Reyes, J. A., Cortassa, S., Kaushik, S., Gonzalez-Freire, M., Patel, B., et al. (2016) · Cell Metabolism

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Cited by 451

Divide and conquer: nucleotide excision repair battles cancer and ageing

Mitchell, J. R., Hoeijmakers, J. H., & Niedernhofer, L. J. (2003) · Current Opinion in Cell Biology

DNA Repair MechanismsGenetics, Aging, and Longevity in Model Organisms

Cited by 160

An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria

Andressoo, J.-O., Mitchell, J. R., de Wit, J., Hoogstraten, D., Volker, M., Toussaint, W., Speksnijder, E., Beems, R. B., van Steeg, H., Jans, J., et al. (2006) · Cancer Cell

DNA Repair MechanismsNuclear Structure and Function

Cited by 78

Health benefits of late-onset metformin treatment every other week in mice

Alfaras, I., Mitchell, S. J., Mora, H., Lugo, D. R., Warren, A., Navas-Enamorado, I., Hoffmann, V., Hine, C., Mitchell, J. R., Le Couteur, D. G., et al. (2017) · npj Aging and Mechanisms of Disease

Metabolism, Diabetes, and CancerGenetics, Aging, and Longevity in Model Organisms

Cited by 68

A review of the biomedical innovations for healthy longevity

Moskalev, A., Anisimov, V., Aliper, A., Artemov, A., Asadullah, K., Belsky, D., Baranova, A., de Grey, A., Dixit, V. D., Debonneuil, E., et al. (2017) · Aging

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 22