Tai, Phillip W. L.

Adeno-associated virus vector as a platform for gene therapy delivery

Wang, D., Tai, P. W. L., & Gao, G. (2019) · Nature Reviews Drug Discovery

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 2,444

Viral vector platforms within the gene therapy landscape

Bulcha, J. T., Wang, Y., Ma, H., Tai, P. W. L., & Gao, G. (2021) · Signal Transduction and Targeted Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 1,404

Design of tissue-specific regulatory cassettes for high-level rAAV-mediated expression in skeletal and cardiac muscle

Salva, M. Z., Himeda, C. L., Tai, P. W., Nishiuchi, E., Gregorevic, P., Allen, J. M., Finn, E. E., Nguyen, Q. G., Blankinship, M. J., Meuse, L., et al. (2007) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 232

Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses

Chan, Y. K., Wang, S. K., Chu, C. J., Copland, D. A., Letizia, A. J., Costa Verdera, H., Chiang, J. J., Sethi, M., Wang, M. K., Neidermyer, W. J., et al. (2021) · Science Translational Medicine

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 215

Overcoming innate immune barriers that impede AAV gene therapy vectors

Muhuri, M., Maeda, Y., Ma, H., Ram, S., Fitzgerald, K. A., Tai, P. W. L., & Gao, G. (2021) · Journal of Clinical Investigation

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 212

AAV gene therapy for Tay-Sachs disease

Flotte, T. R., Cataltepe, O., Puri, A., Batista, A. R., Moser, R., McKenna-Yasek, D., Douthwright, C., Gernoux, G., Blackwood, M., Mueller, C., et al. (2022) · Nature Medicine

Lysosomal Storage Disorders ResearchVirus-based gene therapy research

Cited by 143

Short DNA Hairpins Compromise Recombinant Adeno-Associated Virus Genome Homogeneity

Xie, J., Mao, Q., Tai, P. W. L., He, R., Ai, J., Su, Q., Zhu, Y., Ma, H., Li, J., Gong, S., et al. (2017) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 102

Adeno-associated Virus Genome Population Sequencing Achieves Full Vector Genome Resolution and Reveals Human-Vector Chimeras

Tai, P. W. L., Xie, J., Fong, K., Seetin, M., Heiner, C., Su, Q., Weiand, M., Wilmot, D., Zapp, M. L., & Gao, G. (2018) · Molecular Therapy - Methods & Clinical Development

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 102

Human and Insect Cell-Produced Recombinant Adeno-Associated Viruses Show Differences in Genome Heterogeneity

Tran, N. T., Lecomte, E., Saleun, S., Namkung, S., Robin, C., Weber, K., Devine, E., Blouin, V., Adjali, O., Ayuso, E., et al. (2022) · Human Gene Therapy

Virus-based gene therapy researchViral Infectious Diseases and Gene Expression in Insects

Cited by 74

Structural characterization of a novel human adeno-associated virus capsid with neurotropic properties

Hsu, H.-L., Brown, A., Loveland, A. B., Lotun, A., Xu, M., Luo, L., Xu, G., Li, J., Ren, L., Su, Q., et al. (2020) · Nature Communications

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 63

Circumventing cellular immunity by miR142-mediated regulation sufficiently supports rAAV-delivered OVA expression without activating humoral immunity

Xiao, Y., Muhuri, M., Li, S., Qin, W., Xu, G., Luo, L., Li, J., Letizia, A. J., Wang, S. K., Chan, Y. K., et al. (2019) · JCI Insight

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 53

Rational engineering of a functional CpG-free ITR for AAV gene therapy

Pan, X., Yue, Y., Boftsi, M., Wasala, L. P., Tran, N. T., Zhang, K., Pintel, D. J., Tai, P. W. L., & Duan, D. (2022) · Gene Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 53

Novel Combinatorial MicroRNA-Binding Sites in AAV Vectors Synergistically Diminish Antigen Presentation and Transgene Immunity for Efficient and Stable Transduction

Muhuri, M., Zhan, W., Maeda, Y., Li, J., Lotun, A., Chen, J., Sylvia, K., Dasgupta, I., Arjomandnejad, M., Nixon, T., et al. (2021) · Frontiers in Immunology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 50

The AAV2.7m8 capsid packages a higher degree of heterogeneous vector genomes than AAV2

Cui, M., Su, Q., Yip, M., McGowan, J., Punzo, C., Gao, G., & Tai, P. W. L. (2024) · Gene Therapy

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 20

Low-Dose Recombinant Adeno-Associated Virus-Mediated Inhibition of Vascular Endothelial Growth Factor Can Treat Neovascular Pathologies Without Inducing Retinal Vasculitis

Cheng, S.-Y., Luo, Y., Malachi, A., Ko, J., Su, Q., Xie, J., Tian, B., Lin, H., Ke, X., Zheng, Q., et al. (2021) · Human Gene Therapy

Retinal Diseases and TreatmentsVirus-based gene therapy research

Cited by 14