Costello, Joseph F.

Integrative analysis of 111 reference human epigenomes

Roadmap Epigenomics Consortium, Kundaje, A., Meuleman, W., Ernst, J., Bilenky, M., Yen, A., Heravi-Moussavi, A., Kheradpour, P., Zhang, Z., Wang, J., et al. (2015) · Nature

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 6,368

The clonal and mutational evolution spectrum of primary triple-negative breast cancers

Shah, S. P., Roth, A., Goya, R., Oloumi, A., Ha, G., Zhao, Y., Turashvili, G., Ding, J., Tse, K., Haffari, G., et al. (2012) · Nature

Cancer Genomics and DiagnosticsBreast Cancer Treatment Studies

Cited by 1,967

The NIH Roadmap Epigenomics Mapping Consortium

Bernstein, B. E., Stamatoyannopoulos, J. A., Costello, J. F., Ren, B., Milosavljevic, A., Meissner, A., Kellis, M., Marra, M. A., Beaudet, A. L., Ecker, J. R., et al. (2010) · Nature Biotechnology

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 1,892

Conserved role of intragenic DNA methylation in regulating alternative promoters

Maunakea, A. K., Nagarajan, R. P., Bilenky, M., Ballinger, T. J., D’Souza, C., Fouse, S. D., Johnson, B. E., Hong, C., Nielsen, C., Zhao, Y., et al. (2010) · Nature

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 1,743

Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma

Johnson, B. E., Mazor, T., Hong, C., Barnes, M., Aihara, K., McLean, C. Y., Fouse, S. D., Yamamoto, S., Ueda, H., Tatsuno, K., et al. (2014) · Science

Glioma Diagnosis and TreatmentCancer Genomics and Diagnostics

Cited by 1,362

miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells

Silber, J., Lim, D. A., Petritsch, C., Persson, A. I., Maunakea, A. K., Yu, M., Vandenberg, S. R., Ginzinger, D. G., James, C. D., Costello, J. F., et al. (2008) · BMC Medicine

MicroRNA in disease regulationGlioma Diagnosis and Treatment

Cited by 957

The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer

Bell, R. J. A., Rube, H. T., Kreig, A., Mancini, A., Fouse, S. D., Nagarajan, R. P., Choi, S., Hong, C., He, D., Pekmezci, M., et al. (2015) · Science

Telomeres, Telomerase, and SenescenceGenomics and Chromatin Dynamics

Cited by 566

Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge

Sturm, D., Bender, S., Jones, D. T. W., Lichter, P., Grill, J., Becher, O., Hawkins, C., Majewski, J., Jones, C., Costello, J. F., et al. (2014) · Nature Reviews Cancer

Glioma Diagnosis and TreatmentCancer Genomics and Diagnostics

Cited by 555

DNA methylation: An epigenetic mark of cellular memory

Kim, M., & Costello, J. (2017) · Experimental & Molecular Medicine

Epigenetics and DNA MethylationGenetic Syndromes and Imprinting

Cited by 450

SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer

He, B., You, L., Uematsu, K., Zang, K., Xu, Z., Lee, A. Y., Costello, J. F., McCormick, F., & Jablons, D. M. (2003) · Proceedings of the National Academy of Sciences

Cytokine Signaling Pathways and InteractionsEpigenetics and DNA Methylation

Cited by 380

Saturation mutagenesis of twenty disease-associated regulatory elements at single base-pair resolution

Kircher, M., Xiong, C., Martin, B., Schubach, M., Inoue, F., Bell, R. J. A., Costello, J. F., Shendure, J., & Ahituv, N. (2019) · Nature Communications

Genomics and Chromatin DynamicsGenetic Associations and Epidemiology

Cited by 234

Epigenetic mechanisms in glioblastoma multiforme

Nagarajan, R. P., & Costello, J. F. (2009) · Seminars in Cancer Biology

Glioma Diagnosis and TreatmentEpigenetics and DNA Methylation

Cited by 176

Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3

Ching, T.-T., Maunakea, A. K., Jun, P., Hong, C., Zardo, G., Pinkel, D., Albertson, D. G., Fridlyand, J., Mao, J.-H., Shchors, K., et al. (2005) · Nature Genetics

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 159

Recurrent KBTBD4 small in-frame insertions and absence of DROSHA deletion or DICER1 mutation differentiate pineal parenchymal tumor of intermediate differentiation (PPTID) from pineoblastoma

Lee, J. C., Mazor, T., Lao, R., Wan, E., Diallo, A. B., Hill, N. S., Thangaraj, N., Wendelsdorf, K., Samuel, D., Kline, C. N., et al. (2019) · Acta Neuropathologica

Glioma Diagnosis and TreatmentSarcoma Diagnosis and Treatment

Cited by 71

Deuterium metabolic imaging reports on tert expression and early response to therapy in cancer

Batsios, G., Taglang, C., Tran, M., Stevers, N., Barger, C., Gillespie, A. M., Ronen, S. M., Costello, J. F., & Viswanath, P. (2022) · Clinical Cancer Research

Cancer, Hypoxia, and MetabolismAdvanced NMR Techniques and Applications

Cited by 40