Rollema, Hans

Varenicline: An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation

Coe, J. W., Brooks, P. R., Vetelino, M. G., Wirtz, M. C., Arnold, E. P., Huang, J., Sands, S. B., Davis, T. I., Lebel, L. A., Fox, C. B., et al. (2005) · Journal of Medicinal Chemistry

Nicotinic Acetylcholine Receptors StudySmoking Behavior and Cessation

Cited by 930

Pharmacological profile of the α4β2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid

Rollema, H., Chambers, L. K., Coe, J. W., Glowa, J., Hurst, R. S., Lebel, L. A., Lu, Y., Mansbach, R. S., Mather, R. J., Rovetti, C. C., et al. (2007) · Neuropharmacology

Nicotinic Acetylcholine Receptors StudySmoking Behavior and Cessation

Cited by 533

Rationale, pharmacology and clinical efficacy of partial agonists of α4β2 nACh receptors for smoking cessation

Rollema, H., Coe, J. W., Chambers, L. K., Hurst, R. S., Stahl, S. M., & Williams, K. E. (2007) · Trends in Pharmacological Sciences

Smoking Behavior and CessationNicotinic Acetylcholine Receptors Study

Cited by 400

Pre‐clinical properties of the α4β2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence

Rollema, H., Shrikhande, A., Ward, K., Tingley III, F., Coe, J., O'Neill, B., Tseng, E., Wang, E., Mather, R., Hurst, R., et al. (2010) · British Journal of Pharmacology

Nicotinic Acetylcholine Receptors StudySmoking Behavior and Cessation

Cited by 162

The α4β2 nicotinic acetylcholine-receptor partial agonist varenicline inhibits both nicotine self-administration following repeated dosing and reinstatement of nicotine seeking in rats

O’Connor, E. C., Parker, D., Rollema, H., & Mead, A. N. (2010) · Psychopharmacology

Smoking Behavior and CessationNicotinic Acetylcholine Receptors Study

Cited by 118

Varenicline has antidepressant-like activity in the forced swim test and augments sertraline's effect

Rollema, H., Guanowsky, V., Mineur, Y. S., Shrikhande, A., Coe, J. W., Seymour, P. A., & Picciotto, M. R. (2009) · European Journal of Pharmacology

Treatment of Major DepressionNicotinic Acetylcholine Receptors Study

Cited by 87

α4β2 nicotinic acetylcholine receptor partial agonists with low intrinsic efficacy have antidepressant-like properties

Mineur, Y. S., Einstein, E. B., Seymour, P. A., Coe, J. W., O'Neill, B. T., Rollema, H., & Picciotto, M. R. (2011) · Behavioural Pharmacology

Nicotinic Acetylcholine Receptors StudyTreatment of Major Depression

Cited by 49