Scheller, Jürgen

The pro- and anti-inflammatory properties of the cytokine interleukin-6

Scheller, J., Chalaris, A., Schmidt-Arras, D., & Rose-John, S. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Cytokine Signaling Pathways and InteractionsRheumatoid Arthritis Research and Therapies

Cited by 3,212

IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

Grivennikov, S., Karin, E., Terzic, J., Mucida, D., Yu, G.-Y., Vallabhapurapu, S., Scheller, J., Rose-John, S., Cheroutre, H., Eckmann, L., et al. (2009) · Cancer Cell

Cytokine Signaling Pathways and InteractionsNF-κB Signaling Pathways

Cited by 2,155

Targeting IL-6 trans-signalling: past, present and future prospects

Rose-John, S., Jenkins, B. J., Garbers, C., Moll, J. M., & Scheller, J. (2023) · Nature Reviews Immunology

Cytokine Signaling Pathways and InteractionsPsoriasis: Treatment and Pathogenesis

Cited by 524

Interleukin-6: from basic biology to selective blockade of pro-inflammatory activities

Scheller, J., Garbers, C., & Rose-John, S. (2014) · Seminars in Immunology

Cytokine Signaling Pathways and InteractionsRheumatoid Arthritis Research and Therapies

Cited by 308

The balance of interleukin (IL)-6, IL-6·soluble IL-6 receptor (sIL-6R), and IL-6·sIL-6R·sgp130 complexes allows simultaneous classic and trans-signaling

Baran, P., Hansen, S., Waetzig, G. H., Akbarzadeh, M., Lamertz, L., Huber, H. J., Ahmadian, M. R., Moll, J. M., & Scheller, J. (2018) · Journal of Biological Chemistry

Cytokine Signaling Pathways and InteractionsReceptor Mechanisms and Signaling

Cited by 235

Therapeutic Targeting of IL-6 Trans Signaling Counteracts STAT3 Control of Experimental Inflammatory Arthritis

Nowell, M. A., Williams, A. S., Carty, S. A., Scheller, J., Hayes, A. J., Jones, G. W., Richards, P. J., Slinn, S., Ernst, M., Jenkins, B. J., et al. (2009) · The Journal of Immunology

Cytokine Signaling Pathways and InteractionsRheumatoid Arthritis Research and Therapies

Cited by 215

Species Specificity of ADAM10 and ADAM17 Proteins in Interleukin-6 (IL-6) Trans-signaling and Novel Role of ADAM10 in Inducible IL-6 Receptor Shedding

Garbers, C., Jänner, N., Chalaris, A., Moss, M. L., Floss, D. M., Meyer, D., Koch-Nolte, F., Rose-John, S., & Scheller, J. (2011) · Journal of Biological Chemistry

Cytokine Signaling Pathways and InteractionsProtease and Inhibitor Mechanisms

Cited by 201

Loss of CD4+ T Cell IL-6R Expression during Inflammation Underlines a Role for IL-6 Trans Signaling in the Local Maintenance of Th17 Cells

Jones, G. W., McLoughlin, R. M., Hammond, V. J., Parker, C. R., Williams, J. D., Malhotra, R., Scheller, J., Williams, A. S., Rose-John, S., Topley, N., et al. (2010) · The Journal of Immunology

Cytokine Signaling Pathways and InteractionsT-cell and B-cell Immunology

Cited by 189

Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model

Barkhausen, T., Tschernig, T., Rosenstiel, P., van Griensven, M., Vonberg, R.-P., Dorsch, M., Mueller-Heine, A., Chalaris, A., Scheller, J., Rose-John, S., et al. (2011) · Critical Care Medicine

Sepsis Diagnosis and TreatmentCytokine Signaling Pathways and Interactions

Cited by 169

The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases

Garbers, C., Monhasery, N., Aparicio-Siegmund, S., Lokau, J., Baran, P., Nowell, M. A., Jones, S. A., Rose-John, S., & Scheller, J. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Cytokine Signaling Pathways and InteractionsProtease and Inhibitor Mechanisms

Cited by 155

IL‐6 Trans‐signaling Controls Liver Regeneration After Partial Hepatectomy

Fazel Modares, N., Polz, R., Haghighi, F., Lamertz, L., Behnke, K., Zhuang, Y., Kordes, C., Häussinger, D., Sorg, U. R., Pfeffer, K., et al. (2019) · Hepatology

Liver physiology and pathologyCytokine Signaling Pathways and Interactions

Cited by 113

Impact of interleukin-6 classic- and trans-signaling on liver damage and regeneration

Drucker, C., Gewiese, J., Malchow, S., Scheller, J., & Rose-John, S. (2010) · Journal of Autoimmunity

Liver physiology and pathologyCytokine Signaling Pathways and Interactions

Cited by 83

Early hepatocyte DNA synthetic response posthepatectomy is modulated by IL-6 trans-signaling and PI3K/AKT activation

Nechemia-Arbely, Y., Shriki, A., Denz, U., Drucker, C., Scheller, J., Raub, J., Pappo, O., Rose-John, S., Galun, E., & Axelrod, J. H. (2011) · Journal of Hepatology

Liver physiology and pathologyCytokine Signaling Pathways and Interactions

Cited by 42

B Cell-Mediated Maintenance of Cluster of Differentiation 169-Positive Cells Is Critical for Liver Regeneration

Behnke, K., Zhuang, Y., Xu, H. C., Sundaram, B., Reich, M., Shinde, P. V., Huang, J., Modares, N. F., Tumanov, A. V., Polz, R., et al. (2018) · Hepatology

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 34

Efficiently Restored Thrombopoietin Production by Ashwell-Morell Receptor and IL-6R Induced Janus Kinase 2/Signal Transducer and Activator of Transcription Signaling Early After Partial Hepatectomy

Reusswig, F., Fazel Modares, N., Brechtenkamp, M., Wienands, L., Krüger, I., Behnke, K., Lee‐Sundlov, M. M., Herebian, D., Scheller, J., Hoffmeister, K. M., et al. (2021) · Hepatology

Platelet Disorders and TreatmentsLiver physiology and pathology

Cited by 28