Finn, Jonathan D.

A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing

Finn, J. D., Smith, A. R., Patel, M. C., Shaw, L., Youniss, M. R., van Heteren, J., Dirstine, T., Ciullo, C., Lescarbeau, R., Seitzer, J., et al. (2018) · Cell Reports

RNA Interference and Gene DeliveryCRISPR and Genetic Engineering

Cited by 878

In vivo genome editing restores haemostasis in a mouse model of haemophilia

Li, H., Haurigot, V., Doyon, Y., Li, T., Wong, S. Y., Bhagwat, A. S., Malani, N., Anguela, X. M., Sharma, R., Ivanciu, L., et al. (2011) · Nature

Hemophilia Treatment and ResearchCRISPR and Genetic Engineering

Cited by 548

X-Linked Thrombophilia with a Mutant Factor IX (Factor IX Padua)

Simioni, P., Tormene, D., Tognin, G., Gavasso, S., Bulato, C., Iacobelli, N. P., Finn, J. D., Spiezia, L., Radu, C., & Arruda, V. R. (2009) · New England Journal of Medicine

Hemophilia Treatment and ResearchBlood Coagulation and Thrombosis Mechanisms

Cited by 394

Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors

Pien, G. C., Basner-Tschakarjan, E., Hui, D. J., Mentlik, A. N., Finn, J. D., Hasbrouck, N. C., Zhou, S., Murphy, S. L., Maus, M. V., Mingozzi, F., et al. (2009) · Journal of Clinical Investigation

Virus-based gene therapy researchImmunotherapy and Immune Responses

Cited by 192

Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8+ T cells

Martino, A. T., Basner-Tschakarjan, E., Markusic, D. M., Finn, J. D., Hinderer, C., Zhou, S., Ostrov, D. A., Srivastava, A., Ertl, H. C. J., Terhorst, C., et al. (2013) · Blood

Virus-based gene therapy researchHemophilia Treatment and Research

Cited by 162

Eradication of neutralizing antibodies to factor VIII in canine hemophilia a after liver gene therapy

Finn, J. D., Ozelo, M. C., Sabatino, D. E., Franck, H. W. G., Merricks, E. P., Crudele, J. M., Zhou, S., Kazazian, H. H., Lillicrap, D., Nichols, T. C., et al. (2010) · Blood

Hemophilia Treatment and ResearchVirus-based gene therapy research

Cited by 157

AAV liver expression of FIX-padua prevents and eradicates FIX inhibitor without increasing thrombogenicity in hemophilia b dogs and mice

Crudele, J. M., Finn, J. D., Siner, J. I., Martin, N. B., Niemeyer, G. P., Zhou, S., Mingozzi, F., Lothrop, C. D., & Arruda, V. R. (2015) · Blood

Hemophilia Treatment and ResearchVirus-based gene therapy research

Cited by 153

Proteasome Inhibitors Decrease AAV2 Capsid derived Peptide Epitope Presentation on MHC Class I Following Transduction

Finn, J. D., Hui, D., Downey, H. D., Dunn, D., Pien, G. C., Mingozzi, F., Zhou, S., & High, K. A. (2010) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 115

Timing of Intensive Immunosuppression Impacts Risk of Transgene Antibodies after AAV Gene Therapy in Nonhuman Primates

Samelson-Jones, B. J., Finn, J. D., Favaro, P., Wright, J. F., & Arruda, V. R. (2020) · Molecular Therapy - Methods & Clinical Development

Virus-based gene therapy researchHemophilia Treatment and Research

Cited by 50

Modulation of CD8+ T cell responses to AAV vectors with IgG-derived MHC class II epitopes

Hui, D. J., Basner-Tschakarjan, E., Chen, Y., Davidson, R. J., Buchlis, G., Yazicioglu, M., Pien, G. C., Finn, J. D., Haurigot, V., Tai, A., et al. (2013) · Molecular Therapy

Virus-based gene therapy researchImmunotherapy and Immune Responses

Cited by 47

Hyperactivity of factor IX Padua (R338L) depends on factor VIIIa cofactor activity

Samelson-Jones, B. J., Finn, J. D., George, L. A., Camire, R. M., & Arruda, V. R. (2019) · JCI Insight

Hemophilia Treatment and ResearchVirus-based gene therapy research

Cited by 44

Evolutionary Insights Into Coagulation Factor IX Padua and Other High-Specific-Activity Variants

Samelson-Jones, B. J., Finn, J. D., Raffini, L. J., Merricks, E. P., Camire, R. M., Nichols, T. C., & Arruda, V. R. (2021) · Blood Advances

Hemophilia Treatment and ResearchBlood Coagulation and Thrombosis Mechanisms

Cited by 31

Characterization of Naturally-Occurring Humoral Immunity to AAV in Sheep

Tellez, J., Van Vliet, K., Tseng, Y.-S., Finn, J. D., Tschernia, N., Almeida-Porada, G., Arruda, V. R., Agbandje-McKenna, M., & Porada, C. D. (2013) · PLoS ONE

Virus-based gene therapy researchHemophilia Treatment and Research

Cited by 18

Empty capsids and macrophage inhibition/depletion increase rAAV transgene expression in joints of both healthy and arthritic mice

Aalbers, C. J., Broekstra, N., van Geldorp, M., Kramer, E., Ramiro, S., Tak, P. P., Vervoordeldonk, M. J., & Finn, J. D. (2017) · Human Gene Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 16