Cathomen, Toni

A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity

Mussolino, C., Morbitzer, R., Lütge, F., Dannemann, N., Lahaye, T., & Cathomen, T. (2011) · Nucleic Acids Research

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 714

Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases

Szczepek, M., Brondani, V., Büchel, J., Serrano, L., Segal, D. J., & Cathomen, T. (2007) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 501

Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells

Holkers, M., Maggio, I., Liu, J., Janssen, J. M., Miselli, F., Mussolino, C., Recchia, A., Cathomen, T., & Gonçalves, M. A. F. V. (2013) · Nucleic Acids Research

Virus-based gene therapy researchCRISPR and Genetic Engineering

Cited by 312

Streptococcus thermophilus CRISPR-cas9 systems enable specific editing of the human genome

Müller, M., Lee, C. M., Gasiunas, G., Davis, T. H., Cradick, T. J., Siksnys, V., Bao, G., Cathomen, T., & Mussolino, C. (2016) · Molecular Therapy

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 254

Inactivation of hepatitis B virus replication in cultured cells and in vivo with engineered transcription activator-like effector nucleases

Bloom, K., Ely, A., Mussolino, C., Cathomen, T., & Arbuthnot, P. (2013) · Molecular Therapy

Hepatitis B Virus StudiesCRISPR and Genetic Engineering

Cited by 217

Custom zinc-finger nucleases for use in human cells

Alwin, S., Gere, M. B., Guhl, E., Effertz, K., Barbas, C. F., Segal, D. J., Weitzman, M. D., & Cathomen, T. (2005) · Molecular Therapy

CRISPR and Genetic EngineeringDNA Repair Mechanisms

Cited by 165

Adenoviral vector DNA for accurate genome editing with engineered nucleases

Holkers, M., Maggio, I., Henriques, S. F. D., Janssen, J. M., Cathomen, T., & Gonçalves, M. A. F. V. (2014) · Nature Methods

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 138

Targeted Genome Modifications Using Integrase-deficient Lentiviral Vectors

Cornu, T. I., & Cathomen, T. (2007) · Molecular Therapy

Virus-based gene therapy researchCRISPR and Genetic Engineering

Cited by 105

Automated generation of gene-edited CAR T cells at clinical scale

Alzubi, J., Lock, D., Rhiel, M., Schmitz, S., Wild, S., Mussolino, C., Hildenbeutel, M., Brandes, C., Rositzka, J., Lennartz, S., et al. (2021) · Molecular Therapy - Methods & Clinical Development

CAR-T cell therapy researchCRISPR and Genetic Engineering

Cited by 53

Human genome editing in the clinic: new challenges in regulatory benefit-risk assessment

Abou-El-Enein, M., Cathomen, T., Ivics, Z., June, C. H., Renner, M., Schneider, C. K., & Bauer, G. (2017) · Cell Stem Cell

CRISPR and Genetic EngineeringBiomedical Ethics and Regulation

Cited by 31

DNA-Binding Activity of Adeno-Associated Virus Rep Is Required for Inverted Terminal Repeat-Dependent Complex Formation with Herpes Simplex Virus ICP8

Alex, M., Weger, S., Mietzsch, M., Slanina, H., Cathomen, T., & Heilbronn, R. (2012) · Journal of Virology

Virus-based gene therapy researchHerpesvirus Infections and Treatments

Cited by 9