Polishchuk, Roman

A Gene Network Regulating Lysosomal Biogenesis and Function

Sardiello, M., Palmieri, M., di Ronza, A., Medina, D. L., Valenza, M., Gennarino, V. A., Di Malta, C., Donaudy, F., Embrione, V., Polishchuk, R. S., et al. (2009) · Science

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 2,543

Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease

Spampanato, C., Feeney, E., Li, L., Cardone, M., Lim, J., Annunziata, F., Zare, H., Polishchuk, R., Puertollano, R., Parenti, G., et al. (2013) · EMBO Molecular Medicine

Lysosomal Storage Disorders ResearchGlycogen Storage Diseases and Myoclonus

Cited by 341

Effective delivery of large genes to the retina by dual AAV vectors

Trapani, I., Colella, P., Sommella, A., Iodice, C., Cesi, G., de Simone, S., Marrocco, E., Rossi, S., Giunti, M., Palfi, A., et al. (2014) · EMBO Molecular Medicine

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 269

Activation of Autophagy, Observed in Liver Tissues From Patients With Wilson Disease and From ATP7B-Deficient Animals, Protects Hepatocytes From Copper-Induced Apoptosis

Polishchuk, E. V., Merolla, A., Lichtmannegger, J., Romano, A., Indrieri, A., Ilyechova, E. Y., Concilli, M., De Cegli, R., Crispino, R., Mariniello, M., et al. (2019) · Gastroenterology

Trace Elements in HealthAutophagy in Disease and Therapy

Cited by 265

Lysosomal fusion and SNARE function are impaired by cholesterol accumulation in lysosomal storage disorders

Fraldi, A., Annunziata, F., Lombardi, A., Kaiser, H., Medina, D. L., Spampanato, C., Fedele, A. O., Polishchuk, R., Sorrentino, N. C., Simons, K., et al. (2010) · The EMBO Journal

Lysosomal Storage Disorders ResearchCellular transport and secretion

Cited by 225

Delivery of raft-associated, GPI-anchored proteins to the apical surface of polarized MDCK cells by a transcytotic pathway

Polishchuk, R., Pentima, A. D., & Lippincott-Schwartz, J. (2004) · Nature Cell Biology

Cellular transport and secretionExtracellular vesicles in disease

Cited by 206

FGF signalling regulates bone growth through autophagy

Cinque, L., Forrester, A., Bartolomeo, R., Svelto, M., Venditti, R., Montefusco, S., Polishchuk, E., Nusco, E., Rossi, A., Medina, D. L., et al. (2015) · Nature

Osteoarthritis Treatment and MechanismsAutophagy in Disease and Therapy

Cited by 199

Intein-mediated protein trans-splicing expands adeno-associated virus transfer capacity in the retina

Tornabene, P., Trapani, I., Minopoli, R., Centrulo, M., Lupo, M., de Simone, S., Tiberi, P., Dell’Aquila, F., Marrocco, E., Iodice, C., et al. (2019) · Science Translational Medicine

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 192

Gene transfer of master autophagy regulator TFEB results in clearance of toxic protein and correction of hepatic disease in alpha‐1‐anti‐trypsin deficiency

Pastore, N., Blomenkamp, K., Annunziata, F., Piccolo, P., Mithbaokar, P., Maria Sepe, R., Vetrini, F., Palmer, D., Ng, P., Polishchuk, E., et al. (2013) · EMBO Molecular Medicine

Autophagy in Disease and TherapyVirus-based gene therapy research

Cited by 142

Improved dual AAV vectors with reduced expression of truncated proteins are safe and effective in the retina of a mouse model of Stargardt disease

Trapani, I., Toriello, E., de Simone, S., Colella, P., Iodice, C., Polishchuk, E. V., Sommella, A., Colecchi, L., Rossi, S., Simonelli, F., et al. (2015) · Human Molecular Genetics

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 94

Myosin7a Deficiency Results in Reduced Retinal Activity Which Is Improved by Gene Therapy

Colella, P., Sommella, A., Marrocco, E., Di Vicino, U., Polishchuk, E., Garrido, M. G., Seeliger, M. W., Polishchuk, R., & Auricchio, A. (2013) · PLoS ONE

Retinal Development and DisordersVirus-based gene therapy research

Cited by 34