Garcia, Sara P.

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

Canver, M. C., Smith, E. C., Sher, F., Pinello, L., Sanjana, N. E., Shalem, O., Chen, D. D., Schupp, P. G., Vinjamur, D. S., Garcia, S. P., et al. (2015) · Nature

Hemoglobinopathies and Related DisordersCRISPR and Genetic Engineering

Cited by 886

In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates

Musunuru, K., Chadwick, A. C., Mizoguchi, T., Garcia, S. P., DeNizio, J. E., Reiss, C. W., Wang, K., Iyer, S., Dutta, C., Clendaniel, V., et al. (2021) · Nature

CRISPR and Genetic EngineeringLipoproteins and Cardiovascular Health

Cited by 793

Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors

Grünewald, J., Zhou, R., Garcia, S. P., Iyer, S., Lareau, C. A., Aryee, M. J., & Joung, J. K. (2019) · Nature

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 663

CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells

Kurt, I. C., Zhou, R., Iyer, S., Garcia, S. P., Miller, B. R., Langner, L. M., Grünewald, J., & Joung, J. K. (2021) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 573

High levels of AAV vector integration into CRISPR-induced DNA breaks

Hanlon, K. S., Kleinstiver, B. P., Garcia, S. P., Zaborowski, M. P., Volak, A., Spirig, S. E., Muller, A., Sousa, A. A., Tsai, S. Q., Bengtsson, N. E., et al. (2019) · Nature Communications

Virus-based gene therapy researchCRISPR and Genetic Engineering

Cited by 431

Assessment of computational methods for the analysis of single-cell ATAC-seq data

Chen, H., Lareau, C., Andreani, T., Vinyard, M. E., Garcia, S. P., Clement, K., Andrade-Navarro, M. A., Buenrostro, J. D., & Pinello, L. (2019) · Genome Biology

Single-cell and spatial transcriptomicsGenomics and Chromatin Dynamics

Cited by 332